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Thyme honey mouth rinse shows promise for Radiation-Induced dry mouth

NCT ID NCT05859711

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether rinsing with thyme honey diluted in water can relieve dry mouth in head and neck cancer patients who had radiation therapy. 90 adults participated, using either thyme honey or salt water rinses three times daily during and after radiation. The goal was to see if honey's natural properties could stimulate saliva and reduce discomfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
thyme honey mouth rinse
What this could lead to
If effective, thyme honey could provide a simple, natural way to relieve dry mouth in cancer survivors after radiation therapy.
What could go wrong
This is a small, completed Phase 4 trial with only 90 participants. The results may not apply to everyone, and honey's high sugar content could affect oral health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

90 people

The number who actually took part.

Started

Feb 2021

Finished

Jun 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients referred to non-palliative head and neck radiotherapy * Total dose of radiation received (50-70 Gy) * Patients with complaint of xerostomia * Age 25-65 years old * Objective dry mouth score from ( 2-5) * Subjective dry mouth score from (1-4) * Undergoing radiotherapy for at least three weeks * Can independently complete the questionnaire Exclusion Criteria: * Have confirmed systemic diseases or medications associated with xerostomia * Have a known allergy to honey * Patients who had salivary glands removal surgery * Patients with salivary gland diseases or malignancy * Vulnerable groups such as pregnant females, prisoners, mentally and physically handicapped individuals.

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Conditions

The condition(s) this trial relates to.

head and neck cancer Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer patients

Contacts and locations

Locations

  • faculty of dentistry- Ain shams university

    Cairo, Egypt