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Magnetic brain zaps could replace antidepressants for some patients

NCT ID NCT05732298

Symptom relief Sponsor: University of Regensburg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a non-invasive brain stimulation method called theta burst stimulation can help people with depression who refuse medication. 72 participants will either start treatment right away or wait four weeks. The goal is to see if the stimulation alone can reduce depression symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
theta burst stimulation (a type of transcranial magnetic stimulation)
What this could lead to
If it works, this could offer a drug-free option for people with depression who cannot or will not take antidepressants.
What could go wrong
This is a small, early-stage trial with only 72 participants. The treatment is not yet proven, and results may not apply to everyone with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * uni- or bipolar depression according to ICD-10 * present episode at least four weeks * 18-70 years old * no intake and rejection of anti-depressant medication and * no adequate anti-depressant medication in the present episode * no or stable non-drug anti-depressant treatment (e.g. psychotherapy) * residency in Germany, German speaking Exclusion Criteria: * contraindications for transcranial magnetic stimulation (electric devices or metal parts in the body such as pacemaker * relevant neurological or internistic diseases according to study investigator * participation in other trials during treatment * pregnancy or breatfeeding * legal care and placement in a psychiatric hospital * active suicidality

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

Contacts and locations

Locations

  • Department of Psychiatry and Psychotherapy

    Regensburg, 93053, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.