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Can therapy heal family rejection? new trial targets LGBTQ+ mental health

NCT ID NCT05766592

Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two types of talk therapy—individual LGBTQ-affirmative CBT and family-based therapy—delivered online to LGBTQ+ adults (age 20+) who have nonaccepting parents. The goal is to see if these therapies reduce depression and anxiety symptoms. The trial is currently recruiting 124 participants in New York, Pennsylvania, Connecticut, and Israel.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
LGBTQ-affirmative cognitive behavioral therapy and attachment-based family therapy
What this could lead to
If successful, this could provide effective therapy options to improve mental health for LGBTQ+ adults facing family rejection.
What could go wrong
This is a Phase 3 trial, but it is still relatively small (124 people) and focuses on specific regions. The therapies may not work for everyone, and results may not apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 124 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * be 20 and older * be fluent in English * self-identify as lesbian, bisexual, queer, pansexual, or other non-heterosexual identity * currently experience elevated depressive or anxiety symptoms (screened initially using a cutoff of ≥ 2.5 on the Brief Symptom Inventory-4 and further confirmed by the BDI and BAI). * report at least moderate levels of parental rejection or low levels of parental acceptance, as measured using the PARSOS. * have at least one rejecting/nonaccepting parent that agrees to participate in the therapy. * live in New York State, Pennsylvania, Connecticut, or Israel. Exclusion Criteria: * report current mental health treatment ≥1 day/month (except for medication management ≤1 day/week) * report beginning a new medication within the past 30 days * exhibit active psychosis or active mania, as assessed by the SCID-Psych Screen. * exhibit active suicidality or active homicidality, as assessed by the SIDAS * be currently legally mandated to attend treatment * demonstrate gross cognitive impairment, as assessed with the Telephone Interview for Cognitive Status * do not have a parent willing to participate

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mental health issue Parent-child relations

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ben-Gurion University Psychotherapy Research Lab

    RECRUITING

    Beersheba, 84105, Israel

  • Yale LGBTQ Mental Health Initiative with the Yale School of Public Health Office

    NOT_YET_RECRUITING

    New York, New York, 10001, United States

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