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Asthma drug shows promise for lost smell after head trauma

NCT ID NCT07171021

Disease control Sponsor: Taichung Veterans General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether theophylline, an asthma drug, could help people who lost their sense of smell after a head injury. 158 patients who had not improved with standard treatments took theophylline or a placebo, plus did smell training for 6 months. The goal was to see if their ability to identify and detect odors improved.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
theophylline
What this could lead to
If it works, this could point toward a treatment for smell loss after head injury.
What could go wrong
This is a small, completed Phase 4 trial. The results may not apply to everyone, and theophylline can cause side effects like nausea or heart issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

158 people

The number who actually took part.

Started

Dec 2020

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * subjects who complained of a complete loss of their smell function (anosmia) after an episode of head injury. Exclusion Criteria: * patients without a complete loss of their smell function * a history of loss of olfactory function before head trauma or sinus surgery * the etiology of loss of olfactory function was suspected to not be caused by head trauma

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Conditions

The condition(s) this trial relates to.

anosmia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Traumatic anosmia

Contacts and locations

Locations

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan