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New combo therapy offers hope for kids with Tough-to-Treat yolk sac tumor

NCT ID NCT06470464

First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 25 times

Summary

This study tested a new combination of thalidomide and chemotherapy (nab-paclitaxel, gemcitabine, and epirubicin) in 20 children with yolk sac tumor that had come back or stopped responding to standard treatments. The goal was to see if this approach could shrink tumors or lower a key tumor marker (AFP). The study is complete, but results are not yet reported.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Shandong Cancer Hospital and Institute

    Jinan, Shandong, 250117, China

Conditions

The condition(s) this trial relates to.

Endodermal Sinus Tumor germ cell tumor Neoplasms, Germ Cell and Embryonal Recurrence yolk sac tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.