Cheap Blood-Fat indexes may spot insulin resistance without fancy lab tests
NCT ID NCT07260201
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether two simple, low-cost blood-fat indexes (TGI and TGI-BMI) can accurately detect insulin resistance, compared to the standard HOMA-IR test that requires a fasting insulin measurement. Researchers analyzed data from 150 adults without diabetes medications. They found both indexes worked well, especially the TGI-BMI in people with obesity. If confirmed, these indexes could make insulin resistance screening more accessible in everyday clinics.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If validated, these simple blood-fat indexes could replace costly insulin tests, making insulin resistance screening easier and cheaper in routine clinics.
- What could go wrong
- This is a small, retrospective study (150 people) that only compares indexes to HOMA-IR, not to hard outcomes like diabetes development. Results may not apply to people on diabetes medications or with other health conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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150 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult patients who underwent routine biochemical testing and metabolic evaluation at Hisar Intercontinental Hospital. Data were obtained retrospectively from medical records. Participants were divided into two cohorts based on insulin resistance status determined by HOMA-IR values: Non-Insulin Resistant (HOMA-IR \< 2.5) Insulin Resistant (HOMA-IR \> 2.5)
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Eligible participants were adults aged 18-65 years with complete fasting biochemical and anthropometric data. Only patients who were not receiving antidiabetic medications at the time of evaluation were included. Exclusion Criteria: * Patients were excluded if they had any of the following: * Known endocrine disorders (e.g., thyroid dysfunction, Cushing's syndrome) * Chronic kidney or liver disease * Active infection or systemic inflammatory disease * Ongoing use of medications known to affect glucose or lipid metabolism (e.g., corticosteroids, statins, metformin, or insulin) * Incomplete or missing laboratory data
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hisar Intercontinental Hospital
Istanbul, Umraniye, 34768, Turkey (Türkiye)
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