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New study aims to make testicular cancer surgery less painful

NCT ID NCT06828185

Symptom relief Sponsor: Loma Linda University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study compares two standard surgical techniques for removing a testicle due to cancer. One method cuts through a muscle layer (external oblique fascia), while the other spares it. Researchers want to see if sparing the muscle leads to less pain, less need for painkillers, and fewer complications after surgery. About 80 men with suspected testicular cancer will take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Radical inguinal orchiectomy (standard) vs. external oblique fascia sparing orchiectomy
What this could lead to
If it works, this could lead to a less painful recovery and lower opioid use for men undergoing testicular cancer surgery.
What could go wrong
This is a small, early-stage study (80 participants) comparing two standard techniques, so any benefit may be modest or not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants undergoing radical orchiectomy for suspected testicular malignancy * Testicular malignancy can be germ cell tumor or non germ cell tumors, including paratesticular tumors as long as a radical orchiectomy is planned * Participants over 18 years of age who can provide informed consent * Participants not currently using opiates for another reason * Regional and metastatic patients are allowed, as long as participant does not require opiates for pain related to metastatic disease * No contraindication for participant to receive standardized medication pathway in the peri-operative period. Exclusion Criteria: * Clinical T4 disease * History of illicit substance abuse (including prior opioid abuse) except for marijuana * Participants who underwent chemotherapy or radiotherapy prior to orchiectomy * Opioid use within 1 month of study enrollment * Participants with large testis masses requiring skin incision larger than 8 cm in size. * Participants with large testis masses requiring orchiectomy through an incision other than the standard transverse inguinal incision (i.e. hockey stick incision, vertical incision)

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Conditions

The condition(s) this trial relates to.

Neoplasms, Germ Cell and Embryonal Pain, Postoperative testicular cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Testicular cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Loma Linda University

    RECRUITING

    Loma Linda, California, 92354, United States

More trials for these conditions

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