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Jaw nerve block tested in healthy people – no cure, just data

NCT ID NCT05507164

Knowledge-focused Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study aims to understand how a nerve block injection affects jaw muscle activity and bite force in 20 healthy adults. Participants receive one injection, and measurements are taken before and after. The goal is to gather information, not to treat any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-64 years of age * All ethnicity * Male and female sex * Fluent in written/spoken English * Never been diagnosed with TMD * No significant history of orofacial pain * \<5 headaches/month in the 3 months before enrollment * No reported use of a nightguard or occlusal splint 'No' to all questions on self-administered questionnaire for TMD screening: * Pain in jaw or temple on either side of the face in the last 30 days * Stiffness or pain in jaw upon awakening in the last 30 days * Any pain increase/reduction in the jaw/temple region during the last 30 days with * Chewing hard or tough food * Opening mouth or moving jaw forward or to the side * Hold teeth together/clenching/grinding/chewing gum * Using the jaw during activities such as talking, kissing or yawning Exclusion Criteria: * Traumatic injury/ surgery on face or jaw \< 6 months * current orthodontic treatment * pregnant or nursing, * kidney failure or renal dialysis, * heart disease or heart failure, * uncontrolled chronic respiratory disease/ hypertension/ diabetes * history of * seizures * hyperthyroidism * drug or alcohol abuse * psychiatric disorder/conditions requiring hospitalization * chemotherapy/radiation

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Conditions

The condition(s) this trial relates to.

Bites and Stings vascular occlusion disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Occlusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rutgers School of Dental Medicine

    RECRUITING

    Newark, New Jersey, 07103, United States

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