Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New pain drug could replace morphine for teens after back surgery

NCT ID NCT07229495

Symptom relief Sponsor: Peking Union Medical College Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects over the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tegileridine
What this could lead to
If it works, this could offer a new pain relief option for teenagers after spinal surgery, potentially with fewer side effects than morphine.
What could go wrong
This is a Phase 4 trial, but it's still early and small (171 participants). The new drug may not be as effective or safe as hoped, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 171 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 10 years to less than 18 years. * Scheduled to undergo posterior spinal fusion (PSF) surgery for scoliosis under general anesthesia. * American Society of Anesthesiologists (ASA) physical status classification I to III. * The participant and their parent or legal guardian voluntarily provide written informed consent prior to any study-related procedures. Exclusion Criteria: * History of difficult airway, severe respiratory depression (SpO₂ \< 90%), acute or severe bronchial asthma. * History of severe cardiovascular or cerebrovascular disease, such as myocardial infarction, unstable angina, second-degree or higher atrioventricular block, NYHA Class III or higher heart failure, or stroke. * Known or suspected gastrointestinal obstruction, including paralytic ileus. * Known hypersensitivity to opioids or any component of the study drug formulation. * History of psychiatric disorders (e.g., schizophrenia, depression) or cognitive impairment. * Diagnosis of neuromuscular scoliosis or presence of any other chronic pain condition that may interfere with postoperative pain assessment. * Chronic use of opioid analgesics or use of any analgesic medication within 48 hours prior to surgery. * Planned postoperative admission to the intensive care unit (ICU). * Any other condition deemed by the investigator to be inappropriate for participation in the study.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Analgesia, patient-controlled are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

adolescent idiopathic scoliosis agnosia Pain, Postoperative scoliosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia, patient-controlled Pain after surgery Scoliosis; adolescence

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Chao-yang Hospital, Capital Medical University

    Beijing, 100020, China

  • Henan Provincial People's Hospital

    Zhengzhou, Henan, 450003, China

  • Peking Union Medical College Hospital

    Beijing, 100730, China

  • Shanghai Children's Medical Centre, School of Medicine, Shanghai Jiao Tong University

    Shanghai, 200127, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, 330006, China

  • Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

    Shanghai, 200092, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.