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Tears may hold key to spotting dangerous prostate cancer

NCT ID NCT01514669

Diagnosis Sponsor: University of Arkansas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares tears and blood samples from men with and without prostate cancer to find clues that separate aggressive from non-aggressive disease. Researchers aim to develop a simple diagnostic tool. 75 men aged 35-85 who are being checked for prostate cancer will provide samples at one clinic visit.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple, non-invasive test using tears or blood to identify aggressive prostate cancer early.
What could go wrong
This is a small, early-stage study with only 75 participants, so results may not apply to everyone. It's exploring possibilities, not proving a test works yet.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2012

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be selected from those outpatients followed in the Winthrop P. Rockefeller Cancer Institute (located at the University of Arkansas for Medical Sciences).

Ages

35 to 85 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male, 35-85 years old 2. Patients who present for the evaluation of an abnormal exam or test (elevated PSA, abnormal DRE, etc.) 3. Patients who present for the evaluation of a palpable nodule or induration on prostate exam 4. Patients who meet the requirements of Group 1, 2, or 3 of the protocol Exclusion Criteria: 1. Patient \< 35 or \> 85 years of age 2. Concurrent eye infection or trauma, including active conjunctivitis 3. Abnormal production of tears (too much or too little) 4. Any other conditions the PI or staff feels will not fulfill the criteria for study entry or will place the subject in a harmful environment 5. Atypia on prostate biopsy report

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prostate cancer

Contacts and locations

Locations

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, 72205, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.