New software may sharpen laser eye surgery for blurry vision
NCT ID NCT03841253
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a software program that predicts how much vision improvement a special laser treatment can provide for people with irregularly shaped corneas causing astigmatism. About 45 participants with vision quality issues will have their eyes treated, and the software's predictions will be checked against actual results. The goal is to make the laser procedure more accurate and effective.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 45 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2019
- Expected to finish
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Nov 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient presents with topographic irregularly irregular astigmatism and associated quality of vision issues, where TE-PTK would be a more effective treatment than topography-guided ablation or other therapeutic treatment options. Medically suitable for corneal laser refractive surgery. * Calculated residual stromal thickness ≥250 µm. * Subjects should be 21 years of age or older. * Contact lens wearers must stop wearing their contact lenses one week per decade of wear before baseline measurements in case of hard contact lenses and one week before baseline measurements in case of soft contact lenses. * Patient will be able to understand the patient information and willing to sign an informed consent. * Patient will be willing to comply with all follow-up visits and the respective examinations. Exclusion Criteria: * Patient not being able to tolerate local or topical anesthesia * Autoimmune diseases * Sicca syndrome, dry eye * Herpes viral (herpes simplex) infections * Herpes zoster * Diabetes * Pregnant or nursing women (or who are planning pregnancy during the study) * Patients with a weight of \> 135 kg * Any residual, recurrent or acute ocular disease or abnormality of the eye, e.g. * Cataract * Suspected glaucoma or an intraocular pressure \> 21 mm of Hg * Corneal disease * Corneal thinning disorder, e.g. keratoconus, * Pellucid marginal corneal degeneration * Dystrophy of the basal membrane * Corneal oedema * Exudative macular degeneration * Infection * Any residual, recurrent, or active abnormality of the cornea to be treated, e.g. * Existing corneal implant * Corneal lesion * Unstable refraction * Connective tissue disease * Dry eye
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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London Vision Clinic
London, W1G 7LA, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.