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Zapping the brain to find lost words: new hope for stroke survivors?
NCT ID NCT04166513
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a gentle electrical current applied to the scalp (tDCS) during speech therapy could help people with chronic aphasia—a language disorder after stroke—recover their ability to name objects and read words. Twenty-five adults with long-term aphasia received both real and sham stimulation while doing picture-naming and reading tasks. The goal was to see if the brain stimulation boosted the effects of speech therapy and changed brain activity patterns.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- targeted transcranial direct current stimulation (tDCS)
- What this could lead to
- If it works, this could point toward a non-invasive way to boost speech therapy for people with long-term aphasia after stroke.
- What could go wrong
- This is a small, completed study with only 25 participants and no control group for the stimulation alone. Results may not apply to all types of aphasia or stroke survivors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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25 people
The number who actually took part.
- Started
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Dec 2019
- Finished
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Jul 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 85 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with a language deficit from focal neurologic damage (e.g. stroke, tumor). * Patients must be adults and have English-language fluency. * Patients must be eligible to undergo MRI. Exclusion Criteria: * Advanced neurodegenerative disease (i.e. Stage 3 Alzheimer's disease) or neurologic disorder (e.g. idiopathic epilepsy, Parkinson's disease, ALS) * Severe psychopathology (e.g. schizophrenia, bipolar disorder, acute major depressive episode) * No suspected or diagnosed uncorrectable hearing or vision difficulties, or developmental disabilities (i.e. intellectual disability or learning disability). * Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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