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Zapping aggression: could a headset tame impulsive outbursts?

NCT ID NCT04732052

Disease control Sponsor: Dr. Najat Khalifa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This clinical trial is testing whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce impulsivity and aggression in adults with developmental disabilities. The study will involve 60 participants who have a developmental disability and a recent history of aggressive behavior. Half will receive active tDCS, while the other half will receive a sham (placebo) treatment, to see if the brain stimulation can help lower aggressive symptoms and improve behavior.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS), a non-invasive brain stimulation device
What this could lead to
If effective, tDCS could offer a non-drug, non-invasive way to reduce aggressive behavior and impulsivity in adults with developmental disabilities, potentially improving quality of life and reducing the need for restrictive measures.
What could go wrong
This is an early-stage trial with a small number of participants (60), so results may not be conclusive or widely applicable. The treatment may not work for everyone, and there is a risk of side effects, though tDCS is generally considered safe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2022

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-64 years * Diagnosis of a developmental disability * History of one or more incidents of aggression in the last month * Consent to participate in the trial by the individual or their Substitute Decision Maker Exclusion Criteria: * History of epilepsy or seizures * History of acquired brain injury * Having metal in the brain/skull, e.g. splinters, fragments or clips * Having a cochlear implant * Having an implanted neuro-stimulator (e.g. direct brain stimulation, epidural/subdural stimulation, vagal nerve stimulation) * History of brain surgery of procedure * History of severe adverse reaction to tDCS * Having a cardiac pacemaker or intracardiac lines * Current alcohol or drug misuse * Having a sensitive scalp

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Conditions

The condition(s) this trial relates to.

Aggression developmental disability

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aggression

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Providence Care Hospital

    RECRUITING

    Kingston, Ontario, K7L 4X3, Canada

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