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New drug safety check for Hard-to-Treat lymphoma patients

NCT ID NCT05228158

Disease control Sponsor: Eisai Co., Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study monitors the safety of the drug tazemetostat in 145 people with a type of lymphoma (follicular lymphoma) that has come back or not responded to treatment and has a specific gene change (EZH2 mutation). Researchers are tracking side effects and serious reactions during everyday use in Japan. The goal is to understand how safe the drug is in real-world practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 145 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2021

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation will be enrolled in this study.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants with relapsed or refractory follicular lymphoma with EZH2 gene mutation 2. Participants treated with tazemetostat Exclusion Criteria: 1\. Participants with a history of hypersensitivity to any ingredient of Tazverik

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Conditions

The condition(s) this trial relates to.

follicular lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lymphoma, follicular

Contacts and locations

Locations

  • Eisai Trial Site 1

    Chuo-ku, Tokyo, Japan

  • Eisai Trial Site 101

    Tokushima, Tokushima, Japan

  • Eisai Trial Site 105

    Takamatsu, Kagawa-ken, Japan

  • Eisai Trial Site 106

    Nagoya, Aichi-ken, Japan

  • Eisai Trial Site 107

    Edogawa-ku, Tokyo, Japan

  • Eisai Trial Site 109

    Ebina-shi, Kanagawa, Japan

  • Eisai Trial Site 118

    Kagoshima, Kagoshima-ken, Japan

  • Eisai Trial Site 119

    Chiba, Chiba, Japan

  • Eisai Trial Site 12

    Okayama, Okayama-ken, Japan

  • Eisai Trial Site 122

    Matsusaka-shi, Mie-ken, Japan

  • Eisai Trial Site 124

    Itami-shi, Hyōgo, Japan

  • Eisai Trial Site 125

    Ogaki-shi, Gifi, Japan

  • Eisai Trial Site 127

    Nagasaki, Nagasaki, Japan

  • Eisai Trial Site 130

    Toyohashi, Aichi-ken, Japan

  • Eisai Trial Site 131

    Komaki-shi, Aichi-ken, Japan

  • Eisai Trial Site 133

    Toyota-shi, Aichi-ken, Japan

  • Eisai Trial Site 134

    Iizuka-shi, Fukuoka, Japan

  • Eisai Trial Site 14

    Okayama, Okayama-ken, Japan

  • Eisai Trial Site 140

    Tokorozawa-shi, Saitama, Japan

  • Eisai Trial Site 142

    Tanabe-shi, Wakayama, Japan

  • Eisai Trial Site 144

    Osaka, Osaka, Japan

  • Eisai Trial Site 148

    Hidaka-shi, Saitama, Japan

  • Eisai Trial Site 152

    Saitama-shi, Saitama, Japan

  • Eisai Trial Site 156

    Nagoya, Aichi-ken, Japan

  • Eisai Trial Site 158

    Bunkyo-ku, Tokyo, Japan

  • Eisai Trial Site 159

    Suginami-ku, Tokyo, Japan

  • Eisai Trial Site 161

    Sendai, Miyagi, Japan

  • Eisai Trial Site 162

    Shinjuku-ku, Tokyo, Japan

  • Eisai Trial Site 164

    Hirakata-shi, Osaka, Japan

  • Eisai Trial Site 165

    Osaka, Osaka, Japan

  • Eisai Trial Site 167

    Sapporo, Hokkaido, Japan

  • Eisai Trial Site 169

    Yokosuka-shi, Kanagawa, Japan

  • Eisai Trial Site 17

    Kawasaki-shi, Kanagawa, Japan

  • Eisai Trial Site 170

    Okazaki-shi, Aichi-ken, Japan

  • Eisai Trial Site 174

    Nagoya, Aichi-ken, Japan

  • Eisai Trial Site 175

    Ōtsu, Shiga, Japan

  • Eisai Trial Site 176

    Fukuoka, Fukuoka, Japan

  • Eisai Trial Site 177

    Yokohama, Kanagawa, Japan

  • Eisai Trial Site 178

    Okayama, Okayama-ken, Japan

  • Eisai Trial Site 179

    Osaka, Osaka, Japan

  • Eisai Trial Site 18

    Nakagami-gun, Okinawa, Japan

  • Eisai Trial Site 181

    Seto-shi, Aichi-ken, Japan

  • Eisai Trial Site 183

    Sapporo, Hokkaido, Japan

  • Eisai Trial Site 186

    Yokkaichi-shi, Mie-ken, Japan

  • Eisai Trial Site 187

    Tokushima, Tokushima, Japan

  • Eisai Trial Site 188

    Toyama, Toyama, Japan

  • Eisai Trial Site 189

    Nobeoka-shi, Miyazaki, Japan

  • Eisai Trial Site 190

    Kawasaki-shi, Kanagawa, Japan

  • Eisai Trial Site 192

    Matsumoto-shi, Nagano, Japan

  • Eisai Trial Site 193

    Bunkyo-ku, Tokyo, Japan

  • Eisai Trial Site 195

    Matsudo-shi, Chiba, Japan

  • Eisai Trial Site 197

    Saitama-shi, Saitama, Japan

  • Eisai Trial Site 198

    Kitami-shi, Hokkaido, Japan

  • Eisai Trial Site 199

    Konan-shi, Aichi-ken, Japan

  • Eisai Trial Site 2

    Maniwa-shi, Okayama-ken, Japan

  • Eisai Trial Site 20

    Sakata-shi, Yamagata, Japan

  • Eisai Trial Site 201

    Shimotsuke-shi, Tochigi, Japan

  • Eisai Trial Site 202

    Toshima-ku, Tokyo, Japan

  • Eisai Trial Site 204

    Okinawa-shi, Okinawa, Japan

  • Eisai Trial Site 205

    Yatomi-shi, Aichi-ken, Japan

  • Eisai Trial Site 207

    Kanoya-shi, Kagoshima-ken, Japan

  • Eisai Trial Site 208

    Matsumoto-shi, Nagano, Japan

  • Eisai Trial Site 21

    Nagakute-shi, Aichi-ken, Japan

  • Eisai Trial Site 212

    Akashi-shi, Hyōgo, Japan

  • Eisai Trial Site 213

    Osaka, Osaka, Japan

  • Eisai Trial Site 220

    Osaka, Osaka, Japan

  • Eisai Trial Site 221

    Sakai-shi, Osaka, Japan

  • Eisai Trial Site 222

    Asahikawa-shi, Hokkaido, Japan

  • Eisai Trial Site 223

    Iwata-shi, Shizuoka, Japan

  • Eisai Trial Site 224

    Maebashi, Gunma, Japan

  • Eisai Trial Site 225

    Chiyoda-ku, Tokyo, Japan

  • Eisai Trial Site 226

    Toyokawa-shi, Aichi-ken, Japan

  • Eisai Trial Site 227

    Fukuoka, Fukuoka, Japan

  • Eisai Trial Site 228

    Osaka, Osaka, Japan

  • Eisai Trial Site 229

    Meguro-ku, Tokyo, Japan

  • Eisai Trial Site 230

    Kitakyusyu-shi, Fukuoka, Japan

  • Eisai Trial Site 231

    Taito-ku, Tokyo, Japan

  • Eisai Trial Site 233

    Takatsuki-shi, Osaka, Japan

  • Eisai Trial Site 234

    Hirosaki-shi, Aomori, Japan

  • Eisai Trial Site 235

    Tatebayashi-shi, Gunma, Japan

  • Eisai Trial Site 236

    Wakayama, Wakayama, Japan

  • Eisai Trial Site 237

    Toride-shi, Ibaraki, Japan

  • Eisai Trial Site 238

    Kobe, Hyōgo, Japan

  • Eisai Trial Site 239

    Kawachinagano-shi, Osaka, Japan

  • Eisai Trial Site 24

    Shinagawa-Ku, Tokyo, Japan

  • Eisai Trial Site 240

    Akita, Akita, Japan

  • Eisai Trial Site 241

    Chofu-shi, Tokyo, Japan

  • Eisai Trial Site 242

    Osaki-shi, Miyagi, Japan

  • Eisai Trial Site 243

    Komatsushima-shi, Tokushima, Japan

  • Eisai Trial Site 244

    Koriyama-shi, Fukushima, Japan

  • Eisai Trial Site 245

    Shimotsuke-shi, Tochigi, Japan

  • Eisai Trial Site 246

    Toyama, Toyama, Japan

  • Eisai Trial Site 247

    Saga, Saga-ken, Japan

  • Eisai Trial Site 248

    Shinjuku-ku, Tokyo, Japan

  • Eisai Trial Site 249

    Kita-ku, Tokyo, Japan

  • Eisai Trial Site 25

    Matsuyama, Ehime, Japan

  • Eisai Trial Site 251

    Kashihara-shi, Nara, Japan

  • Eisai Trial Site 252

    Aizuwakayam-shi, Fukushima, Japan

  • Eisai Trial Site 253

    Kumamoto, Kumamoto, Japan

  • Eisai Trial Site 254

    Ageo-shi, Saitama, Japan

  • Eisai Trial Site 26

    Kyoto, Kyoto, Japan

  • Eisai Trial Site 27

    Gifu, Gifu, Japan

  • Eisai Trial Site 28

    Gifu, Gifu, Japan

  • Eisai Trial Site 29

    Hitachi-shi, Ibaraki, Japan

  • Eisai Trial Site 31

    Amagasaki-shi, Hyōgo, Japan

  • Eisai Trial Site 36

    Matsusaka-shi, Mie-ken, Japan

  • Eisai Trial Site 4

    Kyoto, Kyoto, Japan

  • Eisai Trial Site 40

    Izunokuni-shi, Shizuoka, Japan

  • Eisai Trial Site 41

    Okayama, Okayama-ken, Japan

  • Eisai Trial Site 43

    Yokohama, Kanagawa, Japan

  • Eisai Trial Site 44

    Nishinomiya-shi, Hyōgo, Japan

  • Eisai Trial Site 45

    Fujioka-shi, Gunma, Japan

  • Eisai Trial Site 46

    Fukuoka, Fukuoka, Japan

  • Eisai Trial Site 49

    Izumisano, Osaka, Japan

  • Eisai Trial Site 5

    Kashiwa-shi, Chiba, Japan

  • Eisai Trial Site 50

    Minato-ku, Tokyo, Japan

  • Eisai Trial Site 52

    Hiroshima, Hiroshima, Japan

  • Eisai Trial Site 55

    Kumamoto, Kumamoto, Japan

  • Eisai Trial Site 56

    Kyoto, Kyoto, Japan

  • Eisai Trial Site 57

    Fukuyama-shi, Hiroshima, Japan

  • Eisai Trial Site 59

    Kawachinagano-shi, Osaka, Japan

  • Eisai Trial Site 60

    Osaka, Osaka, Japan

  • Eisai Trial Site 71

    Kushiro, Hokkaido, Japan

  • Eisai Trial Site 72

    Akashi-shi, Hyōgo, Japan

  • Eisai Trial Site 76

    Kyoto, Kyoto, Japan

  • Eisai Trial Site 82

    Iwaki, Fukushima, Japan

  • Eisai Trial Site 83

    Yonago-shi, Tottori, Japan

  • Eisai Trial Site 87

    Sagamihara-shi, Kanagawa, Japan

  • Eisai Trial Site 88

    Shizuoka, Shizuoka, Japan

  • Eisai Trial Site 89

    Kobe, Hyōgo, Japan

  • Eisai Trial Site 9

    Nankoku-shi, Kochi, Japan

  • Eisai Trial Site 91

    Nagoya, Aichi-ken, Japan

  • Eisai Trial Site 93

    Kobe, Hyōgo, Japan

  • Eisai Trial Site 96

    Hirosaki-shi, Aomori, Japan

  • Eisai Trial Site 98

    Toyonaka-shi, Osaka, Japan

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Other studies related to the condition(s) this trial covers.