New 'Bottom-Up' surgery could improve rectal cancer outcomes
NCT ID NCT03144765
First seen Apr 18, 2026 · Last updated Jun 20, 2026 · Updated 8 times
Summary
This study tests a new surgical technique called transanal total mesorectal excision (taTME) for rectal cancer. Instead of operating from the abdomen, surgeons work from the anus upward, which may make it easier to remove the tumor completely. The trial includes 100 adults with early to mid-stage rectal cancer and will measure how well the surgery removes the cancer and how safe it is.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Cleveland Clinic Florida
Weston, Florida, 33331, United States
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Florida Hospital
Orlando, Florida, 32804, United States
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Kaiser Permanente
Los Angeles, California, 90027, United States
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Lankenau Institute
Wynnewood, Pennsylvania, 19096, United States
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Mount Sinai Beth Israel
New York, New York, 10003, United States
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Providence Portland Medical Center
Portland, Oregon, 97213, United States
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Toronto Western Hospital
Toronto, Canada
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UC Irvine Hospital
Orange, California, 92868, United States
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University of Massachusetts
Worcester, Massachusetts, 01605, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transanal total mesorectal excision (taTME) surgery
What this could lead to
If successful, this could offer a safer, more effective surgical option for rectal cancer, potentially reducing complications and improving recovery.
What could go wrong
This is a mid-stage trial with only 100 participants and no comparison group. The technique is complex and may not prove better than standard surgery. Long-term outcomes are still unknown.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.