Taste and smell changes in chemo: key to better nutrition?
NCT ID NCT06643026
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how chemotherapy affects taste and smell in 69 people with digestive cancers. Researchers used questionnaires to track changes in food preferences and eating habits before, during, and after the first round of chemo. The goal was to understand how these sensory changes might contribute to malnutrition, a common problem in cancer patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors better understand why some cancer patients struggle with eating, leading to more personalized nutritional support.
- What could go wrong
- This is a small, completed observational study with only 69 participants. It does not test a new treatment, so it cannot directly improve patient outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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69 people
The number who actually took part.
- Started
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Nov 2024
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with malignant digestive tumors receiving active chemotherapy
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Able to complete the proposed questionnaires * Patients over 18 years of age * Non-opposed patients * Digestive cancers starting chemotherapy and/or immunotherapy * Able to eat by mouth Exclusion Criteria: * Concomitant treatment for a non-digestive cancer (excluding basal/spinocellular carcinoma and chronic haemopathy) * Previous ENT surgery (face/neck) * Exclusive enteral feeding (nasogastric tube, gastrostomy) or parenteral nutrition * Previous chemotherapy/immunotherapy \< 5 years * Individuals deprived of liberty by a judicial or administrative decision
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Croix Rousse
Lyon, 69004, France
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Hôpital Edouard Herriot
Lyon, 69003, France
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Hôpital Lyon Sud
Pierre-Bénite, 69495, France
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