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Withdrawn study sought to stop brain 'Storms' after blood clot surgery

NCT ID NCT04966546

Knowledge-focused Sponsor: University of New Mexico Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study planned to test whether the drug memantine could reduce harmful brain waves called spreading depolarizations after surgery for chronic subdural hematoma, a common condition in older adults where fluid compresses the brain. The trial was withdrawn before any participants were enrolled, so no data was collected. The goal was to see if blocking these brain waves could prevent post-surgery confusion or weakness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Memantine Hydrochloride
What this could lead to
If it had worked, this could point toward a treatment to reduce confusion or weakness after brain surgery for chronic subdural hematoma.
What could go wrong
The trial was withdrawn before enrolling anyone, so no results exist. It was a very early feasibility study, and memantine's effect on these brain waves was unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Started

Jun 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Surgical intervention for chronic or subacute SDH * Electrode strip placed at time of surgery (for clinical indication of enhanced seizure monitoring) * Age 18-100 * SD detected within 48h of surgery Exclusion Criteria: * Acute SDH requiring large craniotomy (some acute subacute component within cSDH is acceptable) * Strip not feasible or safe to place at conclusion of surgery * Known or suspected infection * Recurrent surgery * Subjects who previously participated in the study (contralateral or recurrent hematoma) * Severe renal impairment (CrCl 5-29) * Use of other NMDA antagonist * Severe hepatic impairment * Child-Pugh Class C hepatic impairment * Known allergy to memantine * Memantine use at time of admission * Inability to obtain enteral feeding (oral or via NGT) * Patients on acetylcholinesterase inhibitors * Women of child-bearing age who are unwilling to undergo dual contraception for 30 days.

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Conditions

The condition(s) this trial relates to.

Hematoma, Subdural, Chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic subdural hematoma

Contacts and locations

Locations

  • University of New Mexico

    Albuquerque, New Mexico, 87131, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.