Nerve block may replace curare in laparoscopic surgery
NCT ID NCT01628952
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways to relax the abdominal muscles during laparoscopic (keyhole) digestive surgery. One method is a nerve block called TAP block, which numbs the abdominal wall. The other is a standard muscle relaxant drug called curare. The trial involves 60 adults aged 18-75 undergoing laparoscopic surgery. Researchers will measure how well each method relaxes the muscles by checking how much air is needed to inflate the abdomen during surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transversus Abdominis Plane (TAP) block (local anesthetic) and curare (muscle relaxant drug)
- What this could lead to
- If successful, this could show that a nerve block provides adequate muscle relaxation without the side effects of curare, potentially improving recovery after laparoscopic surgery.
- What could go wrong
- This is a small, single-center Phase 4 trial with only 60 participants. The results may not apply to all patients or surgeries, and the nerve block might not work as well as curare in some cases.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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60 people
The number who actually took part.
- Started
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Oct 2012
- Finished
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Mar 2013
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients older than 18 years and under 75 years * Informed consent signed * ASA I, II and III * Patient affiliated to social security Exclusion Criteria: * ASA IV * BMI\> 35 kg / m * Personal or family history of malignant hyperthermia * History of allergy or hypersensitivity to intravenous anesthetics (remifentanil), local anesthetics or muscle relaxants * Contraindications to sevoflurane: a history of malignant hyperthermia, history of liver disease after sevoflurane anesthesia, halogenated agents or hypersensitivity to any of these components. * Contraindications to succinylcholine: hyperkalemia, plasma cholinesterase deficiency nickname, para or tetraplegia more than 24 hours, burns over 24 * Contraindications to cisatracurium: myasthenia * Neuromuscular diseases * Contraindications to local anesthetics: hypersensitivity to local anesthetics of the amide, intravenous regional anesthesia, porphyria, ventricular atrial conduction disturbances, epilepsy uncontrolled by treatment * Pregnancy and lactation * severe coagulation disorders * Inability to understand and give informed consent * Patient under guardianship, curatorship or protected * Indication of use of a hypnotic ketamine (BIS change)
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Sign up to get updates when this study changes or when new studies for The main of this study is to compare the nerve block of the muscles of the abdominal wall between the bilateral tap block and curare are added.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Amiens
Amiens, Picardie, 80054, France