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New pain block may cut opioid use after hernia surgery

NCT ID NCT05177991

Symptom relief Sponsor: Leslie Son Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a longer-lasting pain blocker (Exparel) works better than the standard one (Marcaine) for pain control after hernia repair. About 200 adults having minimally invasive hernia surgery will receive one of the two drugs via a nerve block before surgery. Researchers will track pain scores and how many opioid pills patients need afterward.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Liposomal Bupivacaine (Exparel) and Bupivacaine (Marcaine)
What this could lead to
If Exparel works better, patients could have less pain and need fewer opioid pills after hernia surgery.
What could go wrong
This is a very early, small trial, so results may not be conclusive or apply to all hernia patients. Both drugs are already used, so no major breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2022

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age or older * Have a ventral or inguinal hernia requiring surgical repair Exclusion Criteria: * Less than 18 years of age * Chronic pain patients * Having a defect \>10 cm in transverse dimension * Having a defect \<4 cm * Has an allergy to bupivacaine * Has recurrent hernias as per medical history * A TAP block performed at any time aside from just prior to the start of the procedure * If bupivacaine is mixed with other anesthetics * Under the instance of an emergency surgery (trauma) * Concomitant surgery * History of EtOH abuse * History of liver/kidney dysfunction * If the procedure must be converted to open * Inidividual's weight \< 50kg * Individual's BMI \> 45

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Conditions

The condition(s) this trial relates to.

Hernia, Inguinal Hernia, Ventral

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inguinal hernia Ventral hernia

Contacts and locations

Locations

  • Karl LeBlanc

    Baton Rouge, Louisiana, 70808, United States

More trials for these conditions

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