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Can a drug combo take the pain out of kidney stents?

NCT ID NCT07562282

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether combining tamsulosin with either a standard or half dose of tadalafil can better relieve symptoms caused by ureteric stents, such as pain, urgency, and discomfort. Researchers will enroll 140 adults who have a stent placed after kidney stone removal. The goal is to see which dose combination works best without causing more side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tamsulosin and tadalafil
What this could lead to
If it works, this could point toward a better way to manage uncomfortable stent symptoms after kidney stone surgery.
What could go wrong
This is a small, early-phase study with only 140 participants, so results may not apply to everyone. The benefit over existing treatments is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 71 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- patients older than 18 years of age, with presence of a double-J (DJ) stent (polyurethane) post endoscopic stone removal. Exclusion Criteria: * Patients younger than 18 years of age were excluded. * Patients with a history of prostate or bladder surgery were excluded. * Patients with prior lower urinary tract procedures were excluded. * Patients with cancer were excluded. * Patients with neurological conditions were excluded. * Patients with a history of pelvic radiation were excluded. * Patients with diabetes were excluded. * Patients with kidney dysfunction (acute or chronic) were excluded. * Patients with a solitary kidney were excluded. * Patients with congenital urinary anomalies were excluded. * Patients taking the following medications were excluded: * α-blockers * beta-blockers * calcium channel blockers * 5-alpha reductase inhibitors * PDE5 inhibitors * anticholinergics * nitrates * Patients with cardiac issues were excluded. * Patients with residual stone fragments after surgery were excluded. * Patients with multiple or bilateral ureteral stones were excluded. * Patients with long-term or bilateral stents requiring frequent changes were excluded. * Patients with interstitial cystitis were excluded. * Patients with chronic cystitis were excluded. * Patients with prostatitis were excluded. * Pregnant women were excluded. * Breastfeeding women were excluded. * Patients unavailable for follow-up were excluded.

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis ureterolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney stone Ureteric stone

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ain Shams University Hospital

    RECRUITING

    Cairo, Abbasia, Egypt

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