Could a simple pill replace infusions for aHUS patients?

NCT ID NCT05935215

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 28 times

Summary

This study is for adults with a rare blood disorder called aHUS who are currently receiving antibody infusions. Researchers want to see if switching to a daily pill called iptacopan is safe and works just as well to prevent dangerous blood clots. About 50 participants will take iptacopan for 12 months and be monitored closely.

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Contacts and locations

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Study contacts

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Locations

Novartis Investigative Site
WITHDRAWN

Nanjing, Jiangsu, 210009, China
Novartis Investigative Site
ACTIVE_NOT_RECRUITING

Beijing, 100034, China
Novartis Investigative Site
ACTIVE_NOT_RECRUITING

Beijing, 100730, China
Novartis Investigative Site
WITHDRAWN

Shanghai, 200025, China
Novartis Investigative Site
RECRUITING

Bordeaux, 33076, France
Novartis Investigative Site
RECRUITING

Paris, 75015, France
Novartis Investigative Site
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Paris, 75970, France
Novartis Investigative Site
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Rouen, 76031, France
Novartis Investigative Site
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Toulouse, 31054, France
Novartis Investigative Site
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Tours, 37044, France
Novartis Investigative Site
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Essen, 45147, Germany
Novartis Investigative Site
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Kiel, 24105, Germany
Novartis Investigative Site
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Ranica, BG, 24020, Italy
Novartis Investigative Site
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Milan, MI, 20122, Italy
Novartis Investigative Site
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Roma, RM, 00168, Italy
Novartis Investigative Site
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Matsumoto-shi, Nagano, 3908510, Japan
Novartis Investigative Site
RECRUITING

Iruma-gun, Saitama, 3500495, Japan
Novartis Investigative Site
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Bunkyo Ku, Tokyo, 113-8655, Japan
Novartis Investigative Site
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Santiago Compostela, A Coruna, 15706, Spain
Novartis Investigative Site
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Barcelona, 08036, Spain
Novartis Investigative Site
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Córdoba, 14004, Spain
Novartis Investigative Site
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Málaga, 29010, Spain
Novartis Investigative Site
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Seville, 41013, Spain
Novartis Investigative Site
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Valencia, 46026, Spain
Novartis Investigative Site
WITHDRAWN

Izmir, Balcova, 35340, Turkey (Türkiye)
Novartis Investigative Site
RECRUITING

Köseköy, Kocaeli, 41380, Turkey (Türkiye)
Novartis Investigative Site
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Ankara, Yenimahalle, 06500, Turkey (Türkiye)
Novartis Investigative Site
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Mersin, Yenisehir, 33110, Turkey (Türkiye)
Novartis Investigative Site
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Glasgow, Scotland, G51 4TF, United Kingdom
Novartis Investigative Site
RECRUITING

Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
Novartis Investigative Site
RECRUITING

London, NW1 2BU, United Kingdom

Conditions

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ATYPICAL HEMOLYTIC UREMIC SYNDROME