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New heart surgery technique aims to prevent silent strokes

NCT ID NCT07302659

Disease control Sponsor: China National Center for Cardiovascular Diseases Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new surgical method for heart bypass surgery that avoids touching the aorta, aiming to reduce brain complications like silent strokes. About 380 adults with coronary artery disease will be randomly assigned to either the new no-touch technique or the standard method. The main goal is to see if the new approach lowers the rate of silent brain infarctions and clinical strokes after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Aortic no-touch coronary artery bypass grafting (RIMA-SVG) procedure
What this could lead to
If successful, this technique could reduce the risk of silent brain injury and stroke during heart bypass surgery, making the procedure safer for patients.
What could go wrong
This is a mid-stage trial with 380 participants, so results may not apply to all patients. The new technique is more complex and may have its own risks, such as graft failure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 380 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (\>18 years old) with multivessel coronary artery disease who are scheduled to undergo isolated off-pump coronary artery bypass grafting and who provide informed consent to participate in this study. Exclusion Criteria: * Indications for cardiopulmonary bypass surgery (or no contraindications to on-pump surgery); * Great saphenous vein is unsuitable for use as a graft conduit; * Subclavian artery stenosis or occlusion, or any contraindication to the use of the internal mammary artery as a graft conduit; * History of previous cardiac surgery; * Emergency surgery; * Inability to apply an aortic clamp due to severe ascending aortic calcification; * Expected inability to tolerate MRI or contraindications to MRI (e.g., known intolerance to MRI, an implanted permanent pacemaker, or an anticipated need for permanent pacemaker implantation); * Inability to complete neurocognitive assessment due to language barriers or visual/hearing impairment.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery bypass graft (CABG)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fuwai Hospital Chinese Academy of Medical Sciences

    RECRUITING

    Beijing, China

  • Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen

    NOT_YET_RECRUITING

    Shenzhen, China

  • Peking University First Hospita

    NOT_YET_RECRUITING

    Beijing, China

  • Qingdao Cardiovascular Hospital

    NOT_YET_RECRUITING

    Qingdao, China

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