Neck surgery may help clear brain waste in Alzheimer's patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria 1. The patient or guardian signs the informed consent form; 2. Age 50-80 years (≥50 years, ≤80 years), male or female; 3. The first diagnosis is Alzheimer's disease with dementia; 4. MMSE score ≤24; 5. Positive β-amyloid protein PET imaging findings; 6. HAMD score ≤17; 7. Hachinski score ≤7; 8. No AD-related drug treatment has been received within the past 1 month; 9. ASA grade 1-3 (≥ grade 1, ≤ grade 3); 10. CDR-SB score of 9.5-15.5. Exclusion Criteria 1. Presence of contraindications to MRI, ICG angiography, or PET scan; 2. Presence of contraindications to lumbar puncture; 3. Severe heart disease or unstable hemodynamic status; 4. Severe lung disease, including severe obstructive, restrictive, or mixed ventilatory dysfunction, or acute inflammation within 3 months; 5. Hepatic insufficiency, AST or ALT \>3 times the upper limit of normal; 6. Renal insufficiency, GFR \<60 mL/min or need for blood purification treatment; 7. MRI indicates active or acute intracranial lesions, including intracranial infection, space-occupying lesions, major hemorrhage, and ≥4 lobar microbleeds, etc.; 8. History of cerebral hemorrhage or cerebral infarction with severe residual neurological dysfunction; 9. Blood diseases, bleeding/coagulation disorders, coagulation dysfunction; 10. Abnormal thyroid function; 11. Moderate or severe stenosis of intracranial or cervical vessels with severe residual neurological dysfunction; 12. Severe hypertension not effectively controlled, systolic blood pressure ≥180 mmHg or diastolic blood pressure ≥110 mmHg; 13. The disease requires systemic use of steroids; 14. Drug addiction (including alcohol, narcotics, and alcohol dependence); 15. Severe infectious diseases, including HIV positivity, severe infection, etc.; 16. Severe psychiatric disease or potential suicide risk; 17. Within 3 years after radical surgery for malignant tumor; 18. Participation in other interventional clinical trials within the past three months; 19. In the physician's judgment, poor compliance, inability to complete, or unwillingness to cooperate with regular postoperative follow-up; 20. Other circumstances that the physician considers unsuitable for this clinical trial; 21. Anti-Aβ monoclonal antibody treatment has been received within half a year; 22. Previous neck surgery.