New study tests supplement to fix nutrient gaps in ozempic users
NCT ID NCT07437911
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a nutritional supplement called AG1 can help fill nutrient gaps and improve gut health in 120 adults taking GLP-1 medications like Ozempic or Wegovy. Participants will take either the supplement or a placebo for a period, and researchers will measure changes in their diet, blood nutrient levels, and gut bacteria. The goal is to see if the supplement can support overall health in people using these popular weight-loss drugs.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- AG1 nutritional supplement
- What this could lead to
- If it works, this could show that a simple daily supplement helps GLP-1 users avoid nutrient deficiencies and support gut health while on these medications.
- What could go wrong
- This is a small, early-stage trial with no phase, so results may not apply to everyone. The supplement may not improve nutrient levels or gut health more than a placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Feb 2026
An estimate. Start dates often move.
- Expected to finish
-
Aug 2026
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 59 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Be male or female * Be aged 18-59. * Has a BMI between 20-31.9. * Anyone currently taking GLP-1 medication at their maintenance dose (week 8+), and without any plans to alter their dosage. This includes: Semaglutide (Ozempic®, Wegovy®, Rybelsus®), Liraglutide (Saxenda®, Victoza®), Dulaglutide (Trulicity®), Exenatide (Byetta®, Bydureon®), Lixisenatide (Adlyxin®) * Anyone willing to follow the study protocol, including immediately prior to the all blood tests, duplicating their diet for 72 hours (3 days), refraining from caffeine and exercise for 24 hours, and fasting for 10 hours. * Anyone willing to maintain their current diet, sleep pattern, and activity levels for the duration of the trial. * Anyone willing to avoid introducing any other supplements, medications, or herbal remedies for the duration of this trial. * Anyone who is generally healthy - does not live with any diagnosed uncontrolled chronic disease. * Has access to a consistent weighing scale for the duration of the study. * Resides in the United States. Exclusion Criteria: * Anyone with a diagnosis of Type I or Type II diabetes. * Anyone with a diagnosis of any metabolic health condition, such as hypertension and dyslipidemia. * Anyone who has taken any multivitamin/multimineral supplements within the past 3 months. * Anyone who has taken a probiotic supplement within the past month. * Anyone who has regularly consumed (5 days/week or more) products that target healthy aging, anti-aging, longevity, gut health, energy, or ingestive behaviour (such as cravings), including resveratrol, quercetin, pterostilbene, coQ10, grapefruit, nicotinamide riboside, prebiotic fiber, green tea, niacin (vitamin B3) within the past 2 months. * Anyone who has received an antibiotic, antifungal, antiparasitic, or antiviral treatment within the past 90 days. * Anyone who has a known history of severe digestive disorders or metabolic conditions that impact nutrient absorption or metabolism, including acid reflux, Irritable Bowel Syndrome (IBS), Irritable Bowel Disease (IBD), Crohn's disease, a history of colon resection, gastroparesis, Inborn errors of metabolism (such as PKU), or gastrointestinal tract surgeries. * Anyone with any known allergies or hypersensitivities to any supplement product ingredients. * Anyone with any chronic health conditions that could impact participation in this study, such as asthma, gout, fibromyalgia, chronic inflammatory conditions (such as Crohn's, Lupus, HIV/AIDS), thyroid conditions, cancer (within the past 5 years), mental health disorders, history of serious illness in the last three months, history of substance abuse, or planned surgery during the study period. * Anyone currently pregnant, trying to conceive, or breastfeeding. * Anyone who has undergone a change in hormone therapy (including oral contraceptives) within the past 4 weeks, or is unwilling to maintain their current hormone therapy/oral contraceptive use throughout the course of the study. * Anyone who consumes more than 2 standard alcoholic drinks per day or more than 10 drinks per week, or has within the past 6 months. * Anyone who is currently a smoker or has been a smoker within the past month. * Anyone who follows a specific exclusion diet, including vegan, vegetarian, carnivore, paleo, atkins, or ketogenic.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Gastrointestinal microbiome are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Citruslabs
RECRUITINGSanta Monica, California, 90404-3727, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gut bacteria may hold clues to dozens of diseases
- Does COVID-19 hide in the gut? scientists probe stool for clues
- Can a Weight-Loss drug ease pressure in cirrhosis?
- Could a CoQ10 supplement counteract GLP-1 fatigue and muscle loss?
- Could a Weight-Loss drug change how your body handles alcohol?
- Can a diabetes drug improve joint replacement outcomes?