Sugar-Digesting enzyme trial for short gut patients ends early
NCT ID NCT04604275
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving sucrase, an enzyme that breaks down sugar, could help people with short bowel syndrome and intestinal failure digest sugar better. The goal was to reduce symptoms like bloating, pain, and diarrhea, and help them tolerate more food. However, the trial was terminated early and only enrolled 3 participants, so the results are very limited.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sucrase (an enzyme that helps digest sugar)
- What this could lead to
- If it works, this could help short bowel syndrome patients tolerate more food by mouth or feeding tube, reducing uncomfortable symptoms like bloating and diarrhea.
- What could go wrong
- This was a very small, early-phase trial that was terminated after enrolling only 3 people, so we have very little data. It is unclear if the enzyme is effective or safe in this group.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
3 people
The number who actually took part.
- Started
-
Jan 2022
- Finished
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Sep 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Short bowel syndrome, of all ages, with dependence on parental support to provide at least 50% of fluid or caloric needs. * Must be on diet containing sucrose. * Must be willing and able to sign informed consent * Adult and Pediatric patients (all ages) Exclusion Criteria: * Current IV antibiotic administration for confirmed bout of bacteremia. * No enteral nutrition * Any condition, disease, illness, or circumstance that in the investigator's opinion puts the subject at any undue risk, prevents completion of the study, or interferes with analysis of the study results
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Jackson Memorial Hospital
Miami, Florida, 33136, United States
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University of Miami
Miami, Florida, 33136, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.