Breathing patterns may skew Fluid-Readiness test in ICU shock patients
NCT ID NCT07644494
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 50 shock patients on ventilators to see if their breathing effort changes the accuracy of an ultrasound test that measures a large vein in the belly. Doctors used the test to predict whether giving fluids would help the heart pump more blood. They found that how hard a patient breathes can affect the test's reliability, which may help doctors make better fluid decisions in the ICU.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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50 people
The number who actually took part.
- Started
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Jun 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This prospective observational study was conducted in an intensive care unit of a university hospital and included shock patients receiving ventilation with spontaneous breathing activity
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. defined as shock who has the presence of systolic blood pressure (SBP) ≤ 90 or a \> 40 mmHg decline of SBP in patients known to be hypertensive or mean arterial pressure (MAP) ≤ 70 mmHg or requiring vasopressors to maintain SBP \> 90 mmHg or MAP \> 70 mmHg, along with signs of hypoperfusion (urinary flow \< 0.5 ml/kg/min for \> 2 h, or presence of skin mottling or blood lactate concentration ≥ 2.0 mmol/L); 2. received mechanical ventilation; 3. had the Pulse Indicator Continuous Cardiac Output (PiCCO) catheter for hemodynamic monitoring； 4. had the sign of fluid administration which include: (a) MAP \< 65 mmHg and/or SBP \< 90 mmHg; (b) the need for vasopressors; (c) urinary flow \< 0.5 ml/kg/min for \>2 h; (d) tachycardia; (e) lactic acidosis; or (f) delayed capillary refilling. Exclusion Criteria: 1. were pregnant; 2. were younger than 18 years of age; 3. could not have spontaneous respiratory drive or effort measured; 4. had intra-abdominal pressure ≥ 16 cmH₂O \[15\]; 5. had conditions affecting dIVC measurement, such as ECMO cannulation; 6. had factors precluding clear ultrasound imaging; 7. defined as right ventricular dysfunction who has (a) tricuspid annular plane systolic excursion \< 16 mm; (b) moderate or greater tricuspid regurgitation; (c) moderate or greater pulmonary artery hypertension\[16\]; 8. expected to die within 24 hours; 9. had family members of the patient declined enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Zhongda hospital
Nanjing, Jiangsu, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Non-invasive heart monitor tested against standard method in shock patients