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Study links structural racism to teen brain changes and substance use risk

NCT ID NCT06221839

Knowledge-focused Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study looks at how structural racism—like unequal access to resources—might affect brain structure and decision-making in Puerto Rican teens aged 11 to 14. Researchers will compare teens living in New York and Puerto Rico using interviews and brain scans. The goal is to understand if these social factors increase the risk of substance use, which could guide future prevention efforts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal how societal factors like structural racism influence teen brain development and substance use risk, pointing toward better prevention strategies.
What could go wrong
This is an early observational study with only 72 participants, so findings may not apply to all groups. It measures associations, not cause and effect, and may not lead to direct interventions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Puerto Rican adolescents living in the mainland US and in Puerto Rico, and a parent or caregiver of each adolescent.

Ages

11 to 14 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The adolescent participant is a biological or non-biological child of a member of the original Boricua Youth Study (BYS) sample. 2. The adolescent is between the ages of 11 to 14.5 at the time of recruitment, and 11 to \<15 at the time of study participation. 3. If the parent/caregiver is not an original BYS member, they have provided a consent to contact form. 4. Parent/caregiver is between the ages of 18-64.5 at the time of recruitment and 18 to \<65 at the time of study participation Exclusion Criteria: 1. Major neurological disorder (e.g. seizure disorder) or cognitive impairment (e.g., moderate to severe Autism Spectrum Disorder, Intellectual Disability) 2. Exclusion criteria for the MRI scan only: MRI contraindications (e.g., irremovable metal on the body, pacemaker, braces, etc.; pregnancy (while required by NYSPI).

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Conditions

The condition(s) this trial relates to.

Adolescent Behavior Systemic Racism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Structural racism Substance use risk

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • University of Puerto Rico, Medical Sciences Campus

    RECRUITING

    San Juan, 00921, Puerto Rico