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New combo therapy aims to ease stroke survivors' muscle tightness and pain

NCT ID NCT07482618

Symptom relief Sponsor: Ayse Guc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding tolperison to botulinum toxin injections helps reduce muscle stiffness and nerve pain in stroke survivors. About 40 adults with spastic hemiplegia (one-sided paralysis) will be followed. Researchers will measure spasticity and walking speed to see if the combination works better than botox alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Hemiplegia Patients Hospitalized at Kayseri City Hospital

Ages

18 to 80 months

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability to stand * History of previous hemorrhagic or ischemic stroke * Stroke-related spasticity (MAS ≥2) * Men and women aged 18-80 years * Agreement to participate in the study Exclusion Criteria: * Diabetes patients * people who have undergone orthopedic surgery * Individuals with non-stroke neurological diseases * Those receiving oral antispastic treatment (non-tolperison medications) * Those who have undergone surgery for spasticity * Individuals lacking orientation and cooperation * Those undergoing surgery, such as with intrathecal baclofen * Individuals receiving medical treatment for neuropathic pain * Individuals under 18 and over 80 years of age * History of allergy or hypersensitivity to the medication to be used * Presence of a fixed contracture in the affected extremity

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Conditions

The condition(s) this trial relates to.

hemiplegia Muscle Spasticity spastic hemiplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spastic hemiplegia

Contacts and locations

Locations

  • Kayseri City Hospital Physical Medicine and Rehabilitation

    Kayseri, Kocasinan, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.