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Drug plus movement therapy may boost hand function in chronic stroke

NCT ID NCT02418949

Symptom relief Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new rehab method for people who had a stroke at least 6 months ago and still have hand weakness and stiffness. The approach combined a drug called cyproheptadine with active movement practice to help improve voluntary muscle control and strength. 96 participants took part to see if this combination could make daily hand tasks easier and faster.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

96 people

The number who actually took part.

Start date

Nov 2015

Finished

Mar 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chronic, severe hand hemiparesis resulting from a single stroke (Chedoke- McMaster Stroke Assessment: Stage of Hand 2 or 3) * Single stroke occurring at least 6 months prior to enrollment * Spasticity * Capacity to provide informed consent Exclusion Criteria: * Excessive pain in paretic upper limb * Hemispatial neglect (as assessed by the Behavioral Inattention Test) * Apraxia (as assessed by the FABERS battery) * Botulinum toxin injection in the upper extremity within the past 6 months * Introduction of new anti-spasticity medication within the past 6 months * Orthopaedic impairments * History of seizure disorder * Other major health impairment

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Conditions

The condition(s) this trial relates to.

hemiplegia Muscle Spasticity Paresis stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemiparesis Muscle spasticity Stroke

Contacts and locations

Locations

  • Rehabilitation Institute of Chicago

    Chicago, Illinois, 60611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.