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New algorithm aims to personalize stroke rehab and speed recovery

NCT ID NCT04637984

Knowledge-focused Sponsor: University Hospital of Ferrara Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a tool called PREP2 can help doctors better predict how well stroke patients will recover arm and leg function. The tool combines simple strength tests and brain measurements in the first days after a stroke. Researchers hope that using these predictions will allow therapists to tailor rehabilitation, making it more efficient and improving outcomes for the 200 participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PREP2 algorithm (a combination of clinical assessments and brain measurements to predict recovery)
What this could lead to
If successful, this approach could help doctors and therapists create more personalized rehabilitation plans, potentially speeding up recovery and improving independence after stroke.
What could go wrong
This is a single-site trial with 200 participants, so results may not apply to all stroke patients. The algorithm is a prediction tool, not a treatment, so its impact on actual recovery is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

200 people

The number who actually took part.

Started

May 2019

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * diagnosis of stroke; * new upper and/or lower limb weakness. Exclusion Criteria: * cerebellar or bilateral stroke; * contraindication to TMS; * cognitive or communication impairment precluding informed consent; * assisted walking prior to admission; * severe medical conditions.

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rehabilitation Stroke

Contacts and locations

Locations

  • Department of Neuroscience and Rehabilitation, University Hospital of Ferrara

    Ferrara, Emilia-Romagna, 44124, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.