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Brain scans reveal how learning rewires Stroke-Damaged brains

NCT ID NCT05511467

Knowledge-focused Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how the brain learns new motor skills after a stroke. Forty adults, some with chronic stroke and some healthy, performed a grip-force task while undergoing brain scans. The goal was to understand which brain circuits support recovery and whether learning-based therapies could be improved. The study is complete and focused on gathering knowledge, not testing a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help design better rehabilitation therapies that harness the brain's natural learning processes to improve recovery after stroke.
What could go wrong
This is a small, completed observational study, not a treatment trial. Results may not directly translate into new therapies or apply to all stroke survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Sep 2022

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Stroke survivors (\>6 months) after their index lesion, ≥18 years of age. Healthy adults (≥18 years of age).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA For all participants: * adult volunteers (age ≥18 years) * right-hand dominance as defined by the Edinburgh Handedness Inventory Stroke-specific inclusion criteria: * ischemic or hemorrhagic lesion * subcortical or cortical tissue involvement * chronic phase (\>6 months) after their index lesion * voluntary whole-hand grip force (MRC, Medical Research Council scale for muscle force ≥2) * repeated release (standardized as a reduction of 50% of maximum voluntary contraction measured with a dynamometer) EXCLUSION CRITERIA For all participants: * Presence of any MRI risk factors * substance use disorder * psychotic disorders Stroke-group specific exclusion criteria: * Primary intracerebral hematoma * subarachnoid hemorrhage * bi-hemispheric or cerebellar strokes * other concomitant neurological disorders affecting upper extremity motor function * documented history of dementia before or after stroke * severe aphasia, particularly of receptive nature (NIHSS Language subsection ≥2), affecting their ability to understand the purpose of the study and give informed consent * uncontrolled hypertension despite treatment * intake of tricyclic anti-depressants or neuroleptic medication.

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sensorimotor impairment Stroke

Contacts and locations

Locations

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.