Can we predict who recovers best after stroke surgery?

NCT ID NCT07740018

Knowledge-focused Sponsor: Sohag University Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study looks at people who have had a severe stroke caused by a blocked large blood vessel in the brain. They will undergo a procedure to remove the clot and restore blood flow. The goal is to understand which patient characteristics, imaging findings, and procedural details are linked to better recovery and fewer complications. By identifying these factors, doctors may be able to personalize treatment and improve outcomes for future stroke patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: endovascular thrombectomy (mechanical clot removal)
What this could lead to: If successful, this could help doctors predict which stroke patients will benefit most from clot removal, leading to faster and more personalized treatment decisions.
What could go wrong: This is an observational study with a small number of participants, so findings may not apply to all stroke patients. It does not test a new treatment, so it cannot directly improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * General Criteria (Applicable to All Time Windows) * Age ≥ 18 to 80 years old. * Acute ischemic stroke due to large vessel occlusion (LVO) presenting within 24 hours from symptom onset or last known well. Occlusion involving one of the following vessels: * internal carotid artery (ICA) * M1 segment of the middle cerebral artery (MCA) * A1 segment of the anterior cerebral artery (ACA) * P1 segment of the posterior cerebral artery (PCA) * Basilar artery (BA) * V4 segment of the vertebral artery (VA) * National Institutes of Health Stroke Scale (NIHSS) score ≥ 6. Patients Presenting Within 0-6 Hours from Symptom Onset or Last Known Well , * Alberta Stroke Program Early CT Score (ASPECTS) ≥ 6. Patients presenting 6-24 hours from the last known well, imaging eligibility based on : * Estimated ischemic core volume \< 70 mL. * Ratio of critically hypoperfused tissue to ischemic core (mismatch ratio) ≥ 1.8. * Absolute volume of potentially salvageable tissue (Diffusion to flair mismatch volume) ≥ 15 mL. Exclusion Criteria: * • Patients with stroke resulting from etiologies other than LVO. * Individuals with a history of previous strokes. * Hemorrhagic stroke * Large established infarction (e.g., ASPECTS \< 6 for patients within the early time window or imaging findings not meeting eligibility criteria in the late window). * Patients presenting 6-24 hours from the last known well who do not meet advanced imaging selection criteria (e.g., DEFUSE 3 or DAWN eligibility criteria). * Pre-stroke disability with a modified Rankin Scale (mRS) score ≥2. * Rapid improvement in neurological status to an NIHSS \< 6 or evidence of vessel recanalization prior to randomization.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endovascular thrombectomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Can we predict who recovers best after stroke surgery?

What the study statuses mean