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Second chance: High-Dose radiation for returning lung tumors under study

NCT ID NCT07401615

Knowledge-focused Sponsor: Istituto Clinico Humanitas Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study reviews medical records of 150 patients with inoperable lung cancer that returned after previous radiation. Researchers want to learn if giving another round of high-precision radiation (SBRT) is safe and effective. The goal is to help doctors make better treatment decisions for patients who have few options left.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients treated with Pulmonary stereotactic radiotherapy

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Inoperable primary non-small cell lung cancer or other metastatic primaries with lung metastases, already treated with radical dose SBRT * Inoperable local recurrence (defined as a tumor recurrence overlapping the 50% isodose field) confirmed by documented radiographic findings and/or pathological biopsies within the thoracic area * Patients had previously received curative intent SBRT with a biologically equivalent dose equal or higher than 75 Gy * Stereotactic reirradiation with ablative purposes up to 8 fractions * No active distant metastasis or controlled distant metastasis at the time of re-irradiation * More than 12 months from previous SBRT * PS ≤ 2 Exclusion Criteria: * Previous conventional RT * Reirradiation with palliative doses * Reirradiation with conventionally fractionated or mildly hypofractionated RT

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-small cell lung cancer Pulmonary stereotactic radiotherapy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AOUI Verona, DAI Chirurgia e Oncologia - Radioterapia Oncologica

    NOT_YET_RECRUITING

    Verona, Verona, 37126, Italy

  • AST Papa Giovanni XXIII

    RECRUITING

    Bergamo, Bergamo, 24127, Italy

  • Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center

    NOT_YET_RECRUITING

    Negrar, Verona, 37024, Italy

  • Centro Fondazione Policlinico Universitario "A. Gemelli", Radioterapia Oncologica

    NOT_YET_RECRUITING

    Roma, Roma, 00136, Italy

  • IRCCS Humanitas Research Hospital

    RECRUITING

    Rozzano, Milano, 20089, Italy

  • REM Radioterapia

    NOT_YET_RECRUITING

    Catania, Catania, 95125, Italy

  • Radiation oncology unit, Ospedale San Raffaele

    NOT_YET_RECRUITING

    Milan, Milano, 20132, Italy

  • Radioterapia Oncologica - Ospedale dell'Angelo

    NOT_YET_RECRUITING

    Venezia, Venezia, 30174, Italy

  • Radiotherapy Department, IRCCS Istituto Nazionale Fondazione G. Pascale

    NOT_YET_RECRUITING

    Naples, Napoli, 80131, Italy

  • Radiotherapy Department, Istituto Europeo di Oncologia

    NOT_YET_RECRUITING

    Milan, Milano, 20141, Italy

  • Radiotherapy Department, Ospedale Bellaria Carlo Alberto Pizzardi

    NOT_YET_RECRUITING

    Bologna, Bologna, 40124, Italy

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