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Can your DNA predict how well therapy works?

NCT ID NCT07594080

Knowledge-focused Sponsor: Semmelweis University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how a person's genetic makeup and brain activity influence their sensitivity to both positive and negative life events. Researchers will use genetic data from over 500,000 people and brain scans to identify who might benefit most from stress management therapy. The goal is to develop biomarkers that help match people to the most effective treatments for mental health and well-being.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

125 people

The number who actually took part.

Started

Nov 2022

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Stable mental state * Right-handed * Not taking regular medication (exception: in females, the use of hormonal contraceptives and oral iron supplements is permitted) Exclusion Criteria: * Current somatic or neurological disorder, or a history of such conditions that may affect neurophysiological functioning (poor physical health may influence mental state and thereby affect the results) * Current or past major psychiatric disorder based on medical history or according to DSM-5 diagnostic criteria, with the exception of unipolar depression, anxiety disorders, and eating disorders, provided that: 1. the participant is currently asymptomatic or exhibits only mild residual symptoms, 2. the disorder does not cause significant functional impairment or distress, and 3. there is no absolute indication for pharmacological treatment * Risky or endangering behavior, or lack of adequate insight into illness * Regular use of medication (exception: in females, the use of hormonal contraceptives and oral iron supplements is permitted) * Alcoholism or other substance abuse * Contraindications for fMRI participation: Metal implants that may compromise participant safety during scanning or cause artifacts in image acquisition * Pregnancy

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Conditions

The condition(s) this trial relates to.

Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mental health and general well-being Stress

Contacts and locations

Locations

  • Semmelweis University

    Budapest, 1089, Hungary

More trials for these conditions

Other studies related to the condition(s) this trial covers.