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Can stress patterns in teens predict a loss of joy?

NCT ID NCT07040449

Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This study looks at how stress affects the brain and body of teenagers and whether these responses are linked to anhedonia—the loss of pleasure in things once enjoyed. Researchers will follow 192 adolescents aged 13 to 15 for 20 months, measuring brain activity, stress hormones, and heart rate during mildly stressful tasks. The goal is to see if different patterns of stress response can predict which teens develop anhedonia and how severe it becomes over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Psychosocial stress tasks (Montreal Imaging Stress Task and Trier Social Stress Test for Children)
What this could lead to
If successful, this could help identify early biological markers that predict which teens are at risk for anhedonia, potentially guiding future prevention or early intervention strategies.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly change outcomes. The findings may not apply to all teens, and the measures are complex and exploratory.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 192 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 15 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 13-15 years old at study entry * Ability to understand and sign an assent form * Meets study hearing and vision requirements Exclusion Criteria: * Current use of medications that would interfere with cardiovascular or endocrine assessments * Metal in the body or other MRI exclusion * Medical condition or injury that could confound brain imaging evaluations or interfere with cardiovascular or endocrine assessments * Impaired intellectual functioning * Diagnosed with a neurodevelopmental disability

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Conditions

The condition(s) this trial relates to.

Anhedonia Fractures, Stress

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adolescent development Anhedonia Stress response

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of North Carolina at Chapel Hill

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

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