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Surgery showdown: which operation best treats stubborn constipation?

NCT ID NCT05352074

Disease control Sponsor: Third Military Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial compares two types of colon surgery for people with severe slow-transit constipation that hasn't improved with other treatments. About 252 adults will be randomly assigned to have either a total colectomy (removing the whole colon) or a subtotal colectomy (removing most but not all of the colon). The goal is to see which surgery leads to better bowel function and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgery (total colectomy with ileorectal anastomosis or subtotal colectomy with cecal-rectal anastomosis)
What this could lead to
If successful, this trial could identify which surgical approach offers better relief for people with severe, treatment-resistant constipation.
What could go wrong
This is a surgical trial with inherent risks like infection or bowel complications. Results may not apply to all patients, and surgery is a last resort after other treatments fail.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

252 people

The number who actually took part.

Started

Mar 2022

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria 1. Patients (≥18 years of age) of either sex 2. Patients with conditions in agreement with the Roman IV criteria of functional constipation 3. Patients have less than one complete spontaneous bowel movement per week 4. Patients rely on laxatives to assist defecation for a long time 5. More than 20% the radio-paque markers localized in the colon after 72 hours based on colonic transit studies 6. Patients were refractory to conservative treatment for more than 1 year 7. Patients with a strong desire for surgery Exclusion criteria 1. Pregnant or breast-feeding women 2. Patients with megacolon, megarectum,severe spastic constipation, severe rectocele, rectal prolapse (Oxford Grade IV or above) 3. Patients with colorectal neoplasms 4. Patients with small intestinal slow transit 5. Patients with constipation-predominant irritable bowel syndrome 6. Patients with inflammatory bowel disease 7. Patients with ileostomy 8. Patients with severe psychiatric disease

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Slow transit constipation Surgery

Contacts and locations

Locations

  • Army Medical Center (Daping Hospital)

    Yuzhong, Chongqing Municipality, 400042, China

  • Chengdu Analrectal Hospital

    Chengdu, Sichuan, 610017, China

  • General Hospital of the Eastern Theater Cammand of the PLA

    Nanjing, Jiangsu, 210002, China

  • No. 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army

    Lanzhou, Gansu, 730050, China

  • Qingdao Municipal Hospital

    Qingdao, Shandong, 266011, China

  • Renji Hospital, Shanghai Jiaotong University

    Pudong, Shanghai Municipality, 200127, China

  • Renmin Hospital of Wuhan University

    Wuhan, Hubei, 430060, China

  • Shanghai Pudong New Area People's Hospital

    Pudong, Shanghai Municipality, 201299, China

  • The First Hospital of China Medical University

    Shengyang, Liaoning, 110001, China

  • The General Hospital of Western Theater Command

    Chengdu, Sichuan, 610036, China

  • The Second People's Hospital of Yibin

    Yibin, Sichuan, 644000, China

  • Xijing Hospital

    Xi’an, Shanxi, 710032, China

  • Zhejiang Provincial People's Hospital

    Hangzhou, Zhejiang, 310014, China

  • Zhongnan Hospital of Wuhan University

    Wuhan, Hubei, 430062, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.