New brain zapping technique could ease Parkinson's symptoms without surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 50-85 years, male or female. * Diagnosed with "clinically established" or "clinically probable" Parkinson's disease according to the 2015 MDS Clinical Diagnostic Criteria for Parkinson's Disease. * Hoehn-Yahr stage ≥ 2, and judged by the investigator to be able to cooperate in completing scale-based assessments and MRI examinations. * Stable regimen of anti-Parkinsonian medication for at least 4 weeks before enrollment, and agreement to maintain a stable regimen during the main study phase unless medically necessary to change. * Written informed consent signed by the study participant. Exclusion Criteria: * Non-primary Parkinson's disease or other parkinsonism / atypical parkinsonism. * Previous receipt of invasive neuromodulation therapies such as deep brain stimulation (DBS) or other intracranial implantation/stereotactic brain surgery. * Presence of contraindications or high-risk conditions for transcranial electrical stimulation (e.g., incompatible metal implants/implantable electrical stimulation devices, etc.), or judged by the investigator as unsuitable to receive transcranial electrical stimulation. * Receipt of non-invasive neuromodulation interventions such as transcranial magnetic stimulation or transcranial electrical stimulation within the past six months. * Presence of contraindications to MRI or inability to tolerate MRI examination. * Significant cognitive impairment or severe psychiatric symptoms that prevent completion of assessments or result in poor compliance. * New initiation or dose adjustment of medications or treatments that significantly affect sleep architecture/consciousness status within the past 4 weeks. * History of epilepsy. * Pregnancy or breastfeeding. * Any other condition judged by the investigator as unsuitable for participation in the study.