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Can your own belly fat fix your aching knee?

NCT ID NCT07405840

Disease control Sponsor: Clinical Center of Vojvodina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether stem cells taken from a person's own belly fat can help regenerate knee cartilage and reduce pain from osteoarthritis. Sixty adults with moderate to severe knee arthritis will receive either a stem cell injection or a standard hyaluronic acid shot. Researchers will track pain, stiffness, and function over 12 months to see which treatment works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stromal vascular fraction (SVF) from the patient's own fat tissue
What this could lead to
If it works, this could offer a new way to reduce pain and improve knee function in people with osteoarthritis, potentially delaying or avoiding joint replacement.
What could go wrong
This is a small, single-center trial with 60 people, so results may not apply to everyone. The treatment is still experimental, and long-term benefits or risks are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

60 people

The number who actually took part.

Started

Jun 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥18 years). * Radiologically confirmed knee OA (grades II-IV, Kellgren-Lawrence scale). * KOOS pain score ≤ 60 points. * Symptomatic degenerative knee disease with at least 6 months of persistent pain. * No history of major knee trauma or prolonged immobilization (\>10 days) Exclusion Criteria: * Minors (\<18 years). * Asymptomatic OA (KL grade 0-I). * Severe axial deformity (varus \>10°, valgus \>10°). * Current anticoagulant or antiplatelet therapy. * Intra-articular corticosteroid injection within the past 6 months. * History of major knee trauma or surgery.

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Conditions

The condition(s) this trial relates to.

osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteearthritis

Contacts and locations

Locations

  • University Clinical Center of Vojvodina

    Novi Sad, Vojvodina, 21000, Serbia

More trials for these conditions

Other studies related to the condition(s) this trial covers.