Could a stem cell boost keep T-Cell lymphoma away longer?
NCT ID NCT06724237
First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 5 times
Summary
This study looks at whether giving high-dose chemotherapy followed by a transplant of the patient's own stem cells can help people with peripheral T-cell lymphoma stay in remission longer than just watching and waiting. About 294 adults aged 18 to 75 who are in their first complete remission after initial treatment will be randomly assigned to either the transplant or observation. The goal is to see which approach better prevents the cancer from coming back.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 294 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Apr 2075
An estimate. End dates often move.
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient must be 18 to 75 years of age * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Patient must have histologically proven peripheral T-cell lymphoma (PTCL) in one of the following categories: * Anaplastic large cell lymphoma (ALCL) ALK-negative * Angioimmunoblastic T-cell lymphoma (AITL) * Nodal PTCL with follicular helper T cell (TFH) phenotype * Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) * Patient must have undergone induction treatment with an anthracycline based chemotherapy. * NOTE: Patients who discontinued anthracycline during treatment are eligible as long as they received at least one dose and achieved complete remission * Patient must have achieved radiologic complete remission following induction therapy as defined by the Lugano criteria with a Deauville score between 1-3 by PET-CT * NOTE: There is no central review required. Confirmation of complete remission status is determined by the enrolling institution's review * NOTE: If a patient had a positive bone marrow biopsy at the time of initial diagnosis (pre-induction), a repeat biopsy must be completed post induction to confirm complete remission (CR) * Patient must be eligible for high dose chemotherapy and autologous stem cell transplant (ASCT) per the enrolling institutional guidelines at the transplant center and be ready to proceed with ASCT if randomized to the ASCT arm * Patient must not have active infection requiring intravenous systemic antimicrobial at time of randomization. Antibiotic prophylaxis is acceptable as long as the dose of the medication has been stable for at least 7 days prior to randomization * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Patient must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse during the treatment phase of the study and thereafter according to institutional guidelines * Absolute neutrophil count (ANC) ≥ 1000/mcL (obtained ≤ 14 days prior to protocol randomization) * Platelets ≥ 75,000/mcL (obtained ≤ 14 days prior to protocol randomization) * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (obtained ≤ 14 days prior to protocol randomization) * Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT)(serum glutamic pyruvic transaminase \[SGPT\]) ≤ 3.0 x institutional ULN (obtained ≤ 14 days prior to protocol randomization) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
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Get notified about this study
Sign up to get updates when this study changes or when new studies for Anaplastic large cell lymphoma, ALK-negative are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
144 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Locations
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Alaska Breast Care and Surgery LLC
RECRUITINGAnchorage, Alaska, 99508, United States
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Alaska Oncology and Hematology LLC
RECRUITINGAnchorage, Alaska, 99508, United States
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Alaska Women's Cancer Care
RECRUITINGAnchorage, Alaska, 99508, United States
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Anchorage Associates in Radiation Medicine
RECRUITINGAnchorage, Alaska, 98508, United States
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BASS Medical Group - Lennon
ACTIVE_NOT_RECRUITINGWalnut Creek, California, 94598, United States
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Banner University Medical Center - Tucson
RECRUITINGTucson, Arizona, 85719, United States
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Bay Area Hospital
RECRUITINGCoos Bay, Oregon, 97420, United States
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Beebe Health Campus
RECRUITINGRehoboth Beach, Delaware, 19971, United States
Contact Email: •••••@•••••
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Beebe Medical Center
RECRUITINGLewes, Delaware, 19958, United States
Contact Email: •••••@•••••
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Beebe South Coastal Health Campus
RECRUITINGMillville, Delaware, 19967, United States
Contact Email: •••••@•••••
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Boulder Community Foothills Hospital
ACTIVE_NOT_RECRUITINGBoulder, Colorado, 80303, United States
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Cancer Care Northwest - Spokane South
RECRUITINGSpokane, Washington, 99202, United States
Contact Email: •••••@•••••
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Cancer Care Northwest-North Spokane
RECRUITINGSpokane, Washington, 99218, United States
Contact Email: •••••@•••••
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Cancer Care Northwest-Valley
RECRUITINGSpokane, Washington, 99216, United States
Contact Email: •••••@•••••
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Carolinas Medical Center/Levine Cancer Institute
RECRUITINGCharlotte, North Carolina, 28203, United States
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Christiana Care - Union Hospital
RECRUITINGElkton, Maryland, 21921, United States
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Christiana Care Health System-Christiana Hospital
RECRUITINGNewark, Delaware, 19718, United States
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Christiana Care Health System-Concord Health Center
RECRUITINGChadds Ford, Pennsylvania, 19317, United States
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Christiana Care Health System-Wilmington Hospital
RECRUITINGWilmington, Delaware, 19801, United States
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
Contact Email: •••••@•••••
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Clackamas Radiation Oncology Center
RECRUITINGClackamas, Oregon, 97015, United States
Contact Email: •••••@•••••
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Colorado Blood Cancer Institute
ACTIVE_NOT_RECRUITINGDenver, Colorado, 80218, United States
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Columbus Oncology and Hematology Associates
RECRUITINGDublin, Ohio, 43016, United States
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Columbus Oncology and Hematology Associates Inc
RECRUITINGColumbus, Ohio, 43214, United States
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Contra Costa Regional Medical Center
ACTIVE_NOT_RECRUITINGMartinez, California, 94553-3156, United States
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Delaware Health Center-Grady Cancer Center
RECRUITINGDelaware, Ohio, 43015, United States
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Doctors Hospital
RECRUITINGColumbus, Ohio, 43228, United States
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Drexel Town Square Health Center
RECRUITINGOak Creek, Wisconsin, 53154, United States
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Dublin Methodist Hospital
RECRUITINGDublin, Ohio, 43016, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Fairbanks Memorial Hospital
ACTIVE_NOT_RECRUITINGFairbanks, Alaska, 99701, United States
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Froedtert Menomonee Falls Hospital
RECRUITINGMenomonee Falls, Wisconsin, 53051, United States
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Froedtert West Bend Hospital/Kraemer Cancer Center
RECRUITINGWest Bend, Wisconsin, 53095, United States
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Froedtert and MCW Moorland Reserve Health Center
RECRUITINGNew Berlin, Wisconsin, 53151, United States
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Geisinger Medical Center
RECRUITINGDanville, Pennsylvania, 17822, United States
Contact Email: •••••@•••••
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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITINGWilkes-Barre, Pennsylvania, 18711, United States
Contact Email: •••••@•••••
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Grady Memorial Hospital
RECRUITINGDelaware, Ohio, 43015, United States
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Grant Medical Center
RECRUITINGColumbus, Ohio, 43215, United States
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Helen F Graham Cancer Center
RECRUITINGNewark, Delaware, 19713, United States
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Huntsman Cancer Institute/University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
Contact Email: •••••@•••••
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Indiana University/Melvin and Bren Simon Cancer Center
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Email: •••••@•••••
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Instituto Nacional De Cancerologia de Mexico
RECRUITINGMexico City, Tlalpan, 14080, Mexico
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Jefferson Healthcare
ACTIVE_NOT_RECRUITINGPort Townsend, Washington, 98368, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
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Kadlec Clinic Hematology and Oncology
RECRUITINGKennewick, Washington, 99336, United States
Contact Email: •••••@•••••
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Katmai Oncology Group
RECRUITINGAnchorage, Alaska, 99508, United States
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LSU Health Sciences Center at Shreveport
RECRUITINGShreveport, Louisiana, 71103, United States
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Loyola Center for Health at Burr Ridge
RECRUITINGBurr Ridge, Illinois, 60527, United States
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Loyola Medicine Homer Glen
RECRUITINGHomer Glen, Illinois, 60491, United States
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Loyola University Medical Center
RECRUITINGMaywood, Illinois, 60153, United States
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Marjorie Weinberg Cancer Center at Loyola-Gottlieb
RECRUITINGMelrose Park, Illinois, 60160, United States
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Marshfield Medical Center-Marshfield
RECRUITINGMarshfield, Wisconsin, 54449, United States
Contact Email: •••••@•••••
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Matthews Radiation Oncology Center
RECRUITINGMatthews, North Carolina, 28105, United States
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Mayo Clinic Hospital in Arizona
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic in Florida
RECRUITINGJacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Medical Oncology Hematology Consultants PA
RECRUITINGNewark, Delaware, 19713, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Mercy Health - Paducah Cancer Center
ACTIVE_NOT_RECRUITINGPaducah, Kentucky, 42003, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
Contact Email: •••••@•••••
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Moffitt Cancer Center - McKinley Campus
RECRUITINGTampa, Florida, 33612, United States
Contact Email: •••••@•••••
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Moffitt Cancer Center-International Plaza
RECRUITINGTampa, Florida, 33607, United States
Contact Email: •••••@•••••
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Novant Health Cancer Institute - Huntersville
RECRUITINGHuntersville, North Carolina, 28078, United States
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Novant Health Cancer Institute - Kernersville
RECRUITINGKernersville, North Carolina, 27284, United States
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Novant Health Cancer Institute - Matthews
RECRUITINGMatthews, North Carolina, 28105, United States
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Novant Health Cancer Institute - Mooresville
RECRUITINGMooresville, North Carolina, 28117, United States
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Novant Health Cancer Institute - Mount Airy
RECRUITINGMount Airy, North Carolina, 27030, United States
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Novant Health Cancer Institute - Statesville
RECRUITINGStateville, North Carolina, 28625, United States
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Novant Health Cancer Institute - Thomasville
RECRUITINGThomasville, North Carolina, 27360, United States
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Novant Health Cancer Institute - Wilkesboro
RECRUITINGNorth Wilkesboro, North Carolina, 28659, United States
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Novant Health Forsyth Medical Center
RECRUITINGWinston-Salem, North Carolina, 27103, United States
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Novant Health Presbyterian Medical Center
RECRUITINGCharlotte, North Carolina, 28204, United States
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Novant Health Presbyterian Medical Center Huntersville
RECRUITINGHuntersville, North Carolina, 28078, United States
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Ochsner Medical Center Jefferson
RECRUITINGNew Orleans, Louisiana, 70121, United States
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OhioHealth Mansfield Hospital
RECRUITINGMansfield, Ohio, 44903, United States
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OhioHealth Marion General Hospital
RECRUITINGMarion, Ohio, 43302, United States
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OhioHealth O'Bleness Hospital
RECRUITINGAthens, Ohio, 45701, United States
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OhioHealth Pickerington Methodist Hospital
RECRUITINGPickerington, Ohio, 43147, United States
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OhioHealth Westerville Medical Campus/Westerville Cancer Center
RECRUITINGWesterville, Ohio, 43082, United States
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Oregon Health and Science University
SUSPENDEDPortland, Oregon, 97239, United States
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PeaceHealth Saint John Medical Center
RECRUITINGLongview, Washington, 98632, United States
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PeaceHealth Saint Joseph Medical Center
RECRUITINGBellingham, Washington, 98225, United States
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PeaceHealth Southwest Medical Center
RECRUITINGVancouver, Washington, 98664, United States
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PeaceHealth United General Medical Center
RECRUITINGSedro-Woolley, Washington, 98284, United States
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Presbyterian - Saint Lukes Medical Center - Health One
ACTIVE_NOT_RECRUITINGDenver, Colorado, 80218, United States
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ProHealth D N Greenwald Center
RECRUITINGMukwonago, Wisconsin, 53149, United States
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ProHealth Oconomowoc Memorial Hospital
RECRUITINGOconomowoc, Wisconsin, 53066, United States
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ProHealth Waukesha Memorial Hospital
RECRUITINGWaukesha, Wisconsin, 53188, United States
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Providence Alaska Medical Center
RECRUITINGAnchorage, Alaska, 99508, United States
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Providence Hood River Memorial Hospital
RECRUITINGHood River, Oregon, 97031, United States
Contact Email: •••••@•••••
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Providence Medical Foundation - Santa Rosa
RECRUITINGSanta Rosa, California, 95403, United States
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Providence Newberg Medical Center
RECRUITINGNewberg, Oregon, 97132, United States
Contact Email: •••••@•••••
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Providence Portland Medical Center
RECRUITINGPortland, Oregon, 97213, United States
Contact Email: •••••@•••••
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Providence Queen of The Valley
RECRUITINGNapa, California, 94558, United States
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Providence Regional Cancer Partnership
RECRUITINGEverett, Washington, 98201, United States
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Providence Regional Cancer System-Aberdeen
RECRUITINGAberdeen, Washington, 98520, United States
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Providence Regional Cancer System-Centralia
RECRUITINGCentralia, Washington, 98531, United States
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Providence Regional Cancer System-Lacey
RECRUITINGLacey, Washington, 98503, United States
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Providence Saint Joseph Medical Center/Disney Family Cancer Center
RECRUITINGBurbank, California, 91505, United States
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Providence Saint Mary Regional Cancer Center
RECRUITINGWalla Walla, Washington, 99362, United States
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Providence Saint Vincent Medical Center
RECRUITINGPortland, Oregon, 97225, United States
Contact Email: •••••@•••••
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Providence Santa Rosa Memorial Hospital
RECRUITINGSanta Rosa, California, 95405, United States
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Providence Willamette Falls Medical Center
RECRUITINGOregon City, Oregon, 97045, United States
Contact Email: •••••@•••••
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Riverside Methodist Hospital
RECRUITINGColumbus, Ohio, 43214, United States
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Rocky Mountain Cancer Centers - Centennial
ACTIVE_NOT_RECRUITINGCentennial, Colorado, 80112, United States
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Rocky Mountain Cancer Centers - Swedish
ACTIVE_NOT_RECRUITINGEnglewood, Colorado, 80113, United States
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Rocky Mountain Cancer Centers-Aurora
ACTIVE_NOT_RECRUITINGAurora, Colorado, 80012, United States
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Rocky Mountain Cancer Centers-Boulder
ACTIVE_NOT_RECRUITINGBoulder, Colorado, 80304, United States
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Rocky Mountain Cancer Centers-Lakewood
ACTIVE_NOT_RECRUITINGLakewood, Colorado, 80228, United States
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Rocky Mountain Cancer Centers-Littleton
ACTIVE_NOT_RECRUITINGLittleton, Colorado, 80120, United States
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Rocky Mountain Cancer Centers-Longmont
ACTIVE_NOT_RECRUITINGLongmont, Colorado, 80501, United States
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Rocky Mountain Cancer Centers-Midtown
ACTIVE_NOT_RECRUITINGDenver, Colorado, 80218, United States
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Rocky Mountain Cancer Centers-Rose
ACTIVE_NOT_RECRUITINGDenver, Colorado, 80220, United States
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Rocky Mountain Cancer Centers-Sky Ridge
ACTIVE_NOT_RECRUITINGLone Tree, Colorado, 80124, United States
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Rocky Mountain Cancer Centers-Thornton
ACTIVE_NOT_RECRUITINGThornton, Colorado, 80260, United States
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Rowan Regional Medical Center
RECRUITINGSalisbury, North Carolina, 28144, United States
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Saint Charles Health System
RECRUITINGBend, Oregon, 97701, United States
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Saint Charles Health System-Redmond
RECRUITINGRedmond, Oregon, 97756, United States
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Saint Luke's Cancer Institute - Boise
RECRUITINGBoise, Idaho, 83712, United States
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Saint Luke's Cancer Institute - Fruitland
RECRUITINGFruitland, Idaho, 83619, United States
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Saint Luke's Cancer Institute - Meridian
RECRUITINGMeridian, Idaho, 83642, United States
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Saint Luke's Cancer Institute - Nampa
RECRUITINGNampa, Idaho, 83687, United States
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Saint Luke's Cancer Institute - Twin Falls
RECRUITINGTwin Falls, Idaho, 83301, United States
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Saint Patrick Hospital - Community Hospital
RECRUITINGMissoula, Montana, 59802, United States
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Sibley Memorial Hospital
RECRUITINGWashington D.C., District of Columbia, 20016, United States
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Siteman Cancer Center at Christian Hospital
RECRUITINGSt Louis, Missouri, 63136, United States
Contact Email: •••••@•••••
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Siteman Cancer Center at Saint Peters Hospital
RECRUITINGCity of Saint Peters, Missouri, 63376, United States
Contact Email: •••••@•••••
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Siteman Cancer Center at West County Hospital
RECRUITINGCreve Coeur, Missouri, 63141, United States
Contact Email: •••••@•••••
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
Contact Email: •••••@•••••
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Skagit Regional Health Cancer Care Center
RECRUITINGMount Vernon, Washington, 98274, United States
Contact Email: •••••@•••••
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Swedish Cancer Institute-Edmonds
RECRUITINGEdmonds, Washington, 98026, United States
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Swedish Cancer Institute-Issaquah
RECRUITINGIssaquah, Washington, 98029, United States
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Swedish Medical Center-Ballard Campus
RECRUITINGSeattle, Washington, 98107, United States
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Swedish Medical Center-Cherry Hill
RECRUITINGSeattle, Washington, 98122-5711, United States
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Swedish Medical Center-First Hill
RECRUITINGSeattle, Washington, 98122, United States
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The James Graham Brown Cancer Center at University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
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The Melanoma and Skin Cancer Institute
ACTIVE_NOT_RECRUITINGEnglewood, Colorado, 80113, United States
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The Women's Imaging Center
ACTIVE_NOT_RECRUITINGDenver, Colorado, 80209, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
Contact Email: •••••@•••••
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UNC Lineberger Comprehensive Cancer Center
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Email: •••••@•••••
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UW Cancer Center at ProHealth Care
RECRUITINGWaukesha, Wisconsin, 53188, United States
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University of Alabama at Birmingham Cancer Center
NOT_YET_RECRUITINGBirmingham, Alabama, 35233, United States
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University of Arizona Cancer Center-North Campus
RECRUITINGTucson, Arizona, 85719, United States
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University of Iowa/Holden Comprehensive Cancer Center
RECRUITINGIowa City, Iowa, 52242, United States
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Kansas Cancer Center - Briarcliff
RECRUITINGKansas City, Missouri, 64116, United States
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University of Kansas Cancer Center - Lee's Summit
RECRUITINGLee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
RECRUITINGKansas City, Missouri, 64154, United States
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University of Kansas Cancer Center-Overland Park
RECRUITINGOverland Park, Kansas, 66210, United States
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University of Kansas Hospital-Westwood Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of Rochester
RECRUITINGRochester, New York, 14642, United States
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University of Virginia Cancer Center
RECRUITINGCharlottesville, Virginia, 22908, United States
Contact Email: •••••@•••••
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITINGMadison, Wisconsin, 53718, United States
Contact Email: •••••@•••••
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
Contact Email: •••••@•••••
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UofL Health Medical Center Northeast
RECRUITINGLouisville, Kentucky, 40245, United States
Contact Email: •••••@•••••
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Wake Forest University at Clemmons
RECRUITINGClemmons, North Carolina, 27012, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
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Wayne State University/Karmanos Cancer Institute
RECRUITINGDetroit, Michigan, 48201, United States
Contact Email: •••••@•••••
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Weisberg Cancer Treatment Center
RECRUITINGFarmington Hills, Michigan, 48334, United States
Contact Email: •••••@•••••
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