New radiation technique aims to protect lungs and kidneys in scleroderma stem cell transplants
NCT ID NCT04380831
First seen Apr 01, 2026 · Last updated Jun 22, 2026 · Updated 10 times
Summary
This early-phase trial tests a more precise form of total body radiation (IMRT) combined with the chemotherapy drug cyclophosphamide before a stem cell transplant in 15 people with severe systemic sclerosis (scleroderma). The goal is to see if this approach is safe and can reduce radiation exposure to the lungs and kidneys compared to standard methods. The study focuses on feasibility and side effects, not yet on curing the disease.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cyclophosphamide (chemotherapy) and total body irradiation (radiation therapy)
What this could lead to
If it works, this could lead to a safer stem cell transplant approach for severe scleroderma, reducing damage to lungs and kidneys.
What could go wrong
This is a very early, small pilot study with only 15 people, so results may not apply widely. The treatment involves strong chemo and radiation, which carry serious risks like infection and organ damage.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.