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St. John's wort may alter how your body handles other drugs

NCT ID NCT03482817

Knowledge-focused Sponsor: Max Zeller Soehne AG Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates how a specific extract of St. John's wort (Ze 117) influences key enzymes and transporters that process many common medications. Twenty healthy volunteers take a cocktail of probe drugs alone and then with St. John's wort to measure changes in drug levels. The goal is to understand potential interactions that could affect the safety and effectiveness of other medicines.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
St. John's wort dry extract Ze 117
What this could lead to
If successful, this could help predict how St. John's wort interacts with other medications, improving safe co-prescribing.
What could go wrong
This is a small, early-phase study in healthy volunteers, so results may not apply to patients or predict real-world interactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

20 people

The number who actually took part.

Started

Feb 2018

Finished

Jun 2018

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * written informed consent * Caucasian male or female subjects aged between ≥18 and ≤55years * Physically and mentally healthy * BMI between ≥19 and ≤29 kg/m2, and body weight ≤90 kg * Non-smoker * If female, the pregnancy test at screening and at admission must be negative Exclusion Criteria: * Known or suspected hypersensitivity to study drugs * history of, any clinically significant diseases * Positive test of hepatitis B, hepatitis C or HIV Screening * Known photohypersensitivity

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Drug interaction study

Contacts and locations

Locations

  • Nuvisan GmbH

    Neu-Ulm, Germany