St. John's wort may alter how your body handles other drugs
NCT ID NCT03482817
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates how a specific extract of St. John's wort (Ze 117) influences key enzymes and transporters that process many common medications. Twenty healthy volunteers take a cocktail of probe drugs alone and then with St. John's wort to measure changes in drug levels. The goal is to understand potential interactions that could affect the safety and effectiveness of other medicines.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- St. John's wort dry extract Ze 117
- What this could lead to
- If successful, this could help predict how St. John's wort interacts with other medications, improving safe co-prescribing.
- What could go wrong
- This is a small, early-phase study in healthy volunteers, so results may not apply to patients or predict real-world interactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Nuvisan GmbH
Neu-Ulm, Germany