St. John's wort may alter how your body handles other drugs
NCT ID NCT03482817
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates how a specific extract of St. John's wort (Ze 117) influences key enzymes and transporters that process many common medications. Twenty healthy volunteers take a cocktail of probe drugs alone and then with St. John's wort to measure changes in drug levels. The goal is to understand potential interactions that could affect the safety and effectiveness of other medicines.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
St. John's wort dry extract Ze 117
What this could lead to
If successful, this could help predict how St. John's wort interacts with other medications, improving safe co-prescribing.
What could go wrong
This is a small, early-phase study in healthy volunteers, so results may not apply to patients or predict real-world interactions.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Nuvisan GmbH
Neu-Ulm, Germany