Brain radiation boost may extend cancer control in lung and melanoma patients
NCT ID NCT05522660
First seen Oct 31, 2025 · Last updated Jun 18, 2026 · Updated 39 times
Summary
This study looks at whether adding a precise form of radiation (stereotactic radiosurgery) to standard drug therapy can better control brain metastases in people with melanoma or non-small cell lung cancer. About 180 participants with newly diagnosed, untreated brain metastases will be randomly assigned to receive either standard systemic treatment alone or standard treatment plus radiation. The goal is to see which approach delays brain tumor growth and maintains quality of life.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Azienda ospedaliero-universitaria Senese Siena
RECRUITINGSiena, Italy
Contact Email: •••••@•••••
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Christie NHS Manchester
RECRUITINGManchester, United Kingdom
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Hospital La Fe
RECRUITINGValencia, Spain
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Hospital Puerta de Hierro
RECRUITINGMajadahonda, Spain
Contact Email: •••••@•••••
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Inselspital
RECRUITINGBern, Switzerland
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Instituto Oncologico Veneto IRCCS
NOT_YET_RECRUITINGPadova, Italy
Contact Email: •••••@•••••
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Istituto Nazionale Tumori "Regina Elena"
RECRUITINGRoma, Italy
Contact Email: •••••@•••••
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Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
RECRUITINGNaples, Italy
Contact Email: •••••@•••••
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Kantonsspital Winterthur
RECRUITINGWinterthur, Switzerland
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NKI-AVL
RECRUITINGAmsterdam, Netherlands
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Policlinico Umberto 1
RECRUITINGRome, Italy
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Royal Marsden (Sutton)
RECRUITINGLondon, United Kingdom
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Santa Maria della Misericordia Hospital
RECRUITINGPerugia, Italy
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Universitätsspital Zürich
RECRUITINGZurich, Switzerland
Contact Email: •••••@•••••
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Vall Hebron Institute of Oncology (VHIO)
RECRUITINGBarcelona, Spain
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.