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Which sperm picking method gives IVF the best shot?

NCT ID NCT07825584

Knowledge-focused Sponsor: Center for Reproductive Medicine Bocian Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers are comparing three ways of selecting sperm before injecting it into an egg during ICSI, a common fertility treatment. The methods are conventional preparation, hyaluronan-binding selection (PICSI), and microfluidic selection. The study uses existing medical records from over 12,000 fertility treatment cycles at multiple centres. It asks whether one method leads to better pregnancy outcomes than the others, and whether the answer depends on the man's specific fertility profile, such as high sperm DNA fragmentation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sperm selection methods used before ICSI: conventional preparation, hyaluronan-binding selection, and microfluidic selection
What this could lead to
If one sperm selection method works better for certain male-factor profiles, clinics could tailor ICSI treatment to each couple instead of using a one-size-fits-all approach.
What could go wrong
This is a retrospective study of existing medical records, not a randomized experiment, so differences between groups may reflect patient characteristics rather than the sperm selection method itself. The findings may not apply to all fertility clinics or patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 12,561 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population comprises adult women undergoing ICSI treatment in routine clinical practice across multiple fertility centres. Eligible source ICSI cycles are retrospectively classified according to the sperm-selection strategy used: conventional ICSI, hyaluronan-binding sperm selection (PICSI), or microfluidic sperm selection. The primary analysis includes an unselected all-comers population, with prespecified phenotype-specific analyses according to male-factor characteristics, including sperm DNA fragmentation.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult women undergoing an ICSI source cycle at a participating fertility centre during the study period. * Source cycles performed using conventional ICSI, hyaluronan-binding sperm selection (PICSI), or microfluidic sperm selection. * Availability of routinely collected clinical and embryological data sufficient to classify the sperm-selection strategy and evaluate at least one prespecified study outcome. Exclusion Criteria: * Cycles not involving ICSI. * Records with insufficient or internally inconsistent data preventing reliable identification of the source ICSI cycle or sperm-selection strategy. * Cycles involving combined hyaluronan-binding and microfluidic sperm selection are excluded from the primary three-group comparative analysis and may be evaluated separately in prespecified sensitivity analyses.

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Conditions

The condition(s) this trial relates to.

Abortion, Spontaneous

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Assisted reproductive technology Assisted reproductive technology outcomes

Contacts and locations

Locations

  • Bocian Fertility Clinic, Białystok

    Bialystok, Podlaskie Voivodeship, 15-267, Poland

  • Bocian Fertility Clinic, Gdańsk

    Gdansk, Pomeranian Voivodeship, 80-244, Poland

  • Bocian Fertility Clinic, Katowice

    Katowice, Silesian Voivodeship, 40-081, Poland

  • Bocian Fertility Clinic, Kielce

    Kielce, Świętokrzyskie Voivodeship, 25-435, Poland

  • Bocian Fertility Clinic, Lublin

    Lublin, Lublin Voivodeship, 20-819, Poland

  • Bocian Fertility Clinic, Poznań

    Poznan, Greater Poland Voivodeship, 60-529, Poland

  • Bocian Fertility Clinic, Rzeszów

    Rzeszów, Podkarpackie Voivodeship, 35-309, Poland

  • Bocian Fertility Clinic, Szczecin

    Szczecin, West Pomeranian Voivodeship, 70-225, Poland

  • Bocian Fertility Clinic, Warsaw Śródmieście

    Warsaw, Masovian Voivodeship, 00-193, Poland

  • Bocian Fertility Clinic, Łódź

    Lodz, Łódź Voivodeship, 90-440, Poland

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