Mouth feel may explain why cancer patients stop eating
NCT ID NCT05272917
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at how head and neck cancer patients sense texture, temperature, and spice in their mouths after treatment. Researchers compared 72 patients to healthy volunteers using touch tests and food preference questionnaires. The goal was to understand if changes in mouth sensation affect eating habits and nutrition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help design better dietary support for head and neck cancer patients by understanding how their sense of touch in the mouth affects eating.
- What could go wrong
- This is a small, completed observational study with only 72 participants. It does not test a treatment, so it cannot directly improve health outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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72 people
The number who actually took part.
- Started
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May 2022
- Finished
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Apr 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: All subjects: * Person between 18 and 65 years * Person having given free, informed, express written consent * Person affiliated to a French social security system * Person with a body mass superior to 18 kg/m². * Person able to come once to the Institut Paul Bocuse Patients with head and neck cancer with chemotherapy: \- Patient diagnosed with squamous cell head and neck cancer with the following treatment regimen: Surgery + radiochemotherapy or radiochemotherapy alone Patients with head and neck cancer without chemotherapy: \- Patient diagnosed with squamous cell head and neck cancer with the following treatment regimen: Surgery + radiation therapy or radiation therapy alone Healthy volunteers : * Volunteer who is +/- 5 years of age relative to the patient to whom they are matched. * Volunteer of the same sex as the patient to whom they are matched * Volunteer with the same smoking status as the patient to whom they are matched * Volunteer who has not had cancer within 5 years at the time of inclusion * Volunteer with no current treatment that may affect taste and smell perception Exclusion Criteria: All subjects: * Person with a known food allergy/intolerance (lactose or milk protein) or unable to consume dairy or solid products (e.g., chocolate milk pudding, chocolate jelly) * Person with a known allergy to chili (or capsaicin) * Person with diagnosed total ageusia * Person with diagnosed total anosmia * Person who has used artificial feeding within 2 months prior to inclusion. * Person who has lost more than 10% of baseline weight in the 2 months prior to inclusion * Person deprived of liberty or under guardianship or trusteeship. * Pregnant or breastfeeding woman * Person deprived of liberty by a judicial or administrative decision * Person under guardianship or protection of vulnerable adults * Person with trismus (reduced jaw opening or limited jaw range of motion) * A person who is unable to extend his or her tongue * Person who has had surgery on the mobile tongue and/or base of the tongue * Person unable to swallow soft foods * Person who has had or is suspected of having had Corona Virus Disease (COVID)-19 within the last 6 months. Patients with head and neck cancer: * Patient receiving immunotherapy * Patient treated with surgery only.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre de recherche de l'Institut Paul Bocuse
Écully, 69131, France
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Service d'Oncologie médicale, Hôpital de la Croix-Rousse
Lyon, 69004, France
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