Gum graft showdown: collagen vs. your own tissue for implants
NCT ID NCT05870774
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two ways to thicken gum tissue around dental implants: using a collagen matrix or a small piece of the patient's own connective tissue. Fifty-two adults with thin gums received one of the two treatments. The researchers measured gum thickness, pain, swelling, and aesthetics over 6 months to see which method worked better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- collagen matrix (Fibro-Gide) or connective tissue graft
- What this could lead to
- If successful, this could show that a collagen matrix is a good alternative to using a patient's own tissue for gum thickening around dental implants.
- What could go wrong
- This is a small, completed trial with only 52 participants, so results may not apply to everyone. The collagen matrix might not work as well as the natural graft.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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52 people
The number who actually took part.
- Started
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Oct 2021
- Finished
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May 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 59 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. The presence of written informed consent of the patient to participate in the study; 2. Age from 25 to 59 years; 3. The presence of an included defect in the distal part of the lower jaw with a sufficient volume of bone tissue; 4. Soft tissue thickness \<3 mm on the vestibular side; 5. Adjacent teeth without periodontal pathology, the depth of probing should not exceed 3 mm along the entire dentoalveolar furrow; 6. Satisfactory level of oral hygiene; 7. Patients without concomitant pathology or with concomitant pathology in the compensation stage. Non-inclusion criteria: 1. Age less than 25 and more than 59 years; 2. Hard smokers (more than 10 cigarettes a day); 3. The presence of concomitant pathology in the stage of decompensation; 4. Patients with malignant tumors, as well as patients with a history of radiation and chemotherapy over the past 5 years; 5. Taking medications that affect the healing of soft tissues (nonsteroidal anti-inflammatory drugs, steroid drugs); 6. Pregnancy and breastfeeding; 7. Patients with mental disorders. Exclusion Criteria: 1. Patients with infections either periodontally or periapically, which developed after inclusion in the study; 2. Pregnancy following entrance into the study; 3. Patients having poor oral hygiene or not wanting to carry out oral hygiene measures; 4. Patients who, for one reason or another, could not complete the entire protocol to the end.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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I.M. Sechenov First Moscow State Medical University
Moscow, 119991, Russia
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