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Stitch showdown: small bites may beat large bites for emergency belly surgery

NCT ID NCT07154277

Disease control Sponsor: Dow University of Health Sciences Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether taking smaller, closer stitches (small bites) when closing an emergency belly incision leads to fewer wound infections, less wound opening, and fewer hernias compared to the traditional larger stitches. Two hundred adults having emergency abdominal surgery will be randomly assigned to one of the two closure methods and followed for six months. The goal is to find the safest and most effective technique for these urgent surgeries.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical suture technique (small bite vs large bite closure)
What this could lead to
If small bites work better, this could become the standard way to close emergency abdominal incisions, reducing complications like infections and hernias.
What could go wrong
This is a mid-stage trial with 200 participants, so results may not apply to all patients. The techniques are already used, so no major new risks, but the benefit over large bites is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

200 people

The number who actually took part.

Started

Nov 2023

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ages in between 18-60 year old * All emergency laparotomies (Except trauma) Exclusion Criteria: * Previous surgery with midline incision * Pregnancy * Current immunosuppressive or chemotherapy * Previous incisional hernia after midline incision

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Conditions

The condition(s) this trial relates to.

Incisional Hernia Surgical Wound Dehiscence Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Incisional hernia/prevention and control Laparotomy/standerds Surgical wound dehiscence Surgical wound infection Suture techniques Wound closure techniques

Contacts and locations

Locations

  • Dr. Ruth K. M. Pfau Civil Hospital Karachi

    Karachi, Sindh, 74400, Pakistan

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