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Military study seeks blood clues to Sleep-Pain mystery after surgery

NCT ID NCT03850743

Knowledge-focused Sponsor: Defense and Veterans Center for Integrative Pain Management Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study enrolled 111 active-duty military members and eligible patients undergoing orthopedic surgery. Researchers collected blood samples and survey data to find biomarkers (like microRNA and cytokines) linked to sleep problems and pain before and after surgery. The goal is to understand why some people develop chronic pain and sleep issues while others recover well. No treatment or drug was tested.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify biological markers that predict who will have worse sleep and pain after surgery, potentially guiding future treatments.
What could go wrong
This is an observational study, not a treatment trial. It only looks for patterns in blood samples and surveys, so it won't directly improve health. Results may not apply to non-military populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

111 people

The number who actually took part.

Started

Feb 2019

Finished

Mar 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Active duty service members and DEERS eligible patients who are injured and/or will undergo elective orthopedic surgery. Up to 240 patients will be enrolled in this study at Walter Reed National Military Medical Center

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Active duty military or DEERS eligible individuals * Between the ages of 18 and 60 years old * Able to understand written and spoken English * Eligible for healthcare within Military Health Systems * Having an orthopedic procedure at WRNMMC Exclusion Criteria: * Bleeding Disorder * History of vasovagal response

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post surgical pain and sleep impairment

Contacts and locations

Locations

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20889, United States