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Could low magnesium worsen sleep in depression?

NCT ID NCT07198477

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether low magnesium levels are linked to sleep problems in people with major depressive disorder. Researchers will measure magnesium in the blood of 90 adults and compare it to their sleep quality. The goal is to better understand this possible connection, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If it finds a clear link, it could point toward checking magnesium levels as part of depression care.
What could go wrong
This is a small, early observational study that only looks for a connection—it won't test any treatment. Results may not apply to everyone with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study sample will include 90 psychiatric patients recruited from the outpatient and inpatient clinics of Assiut University Hospital, representing males and females aged 18-60 years. All participants will have a confirmed diagnosis of major depressive disorder based on clinical criteria and will be evaluated using standardized psychiatric assessment tools. Exclusion criteria were designed to rule out metabolic comorbidities, chronic renal conditions, and medication effects that may confound serum magnesium interpretation. Patients unable to complete questionnaires due to cognitive or language difficulties, as well as those with other psychiatric disorders, will also be excluded.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Confirmed diagnosis of major depressive disorder age 18 years and older Ability to complete questionnaires (BDI-II and PSQI; validated Arabic versions) Willing to participate and provide informed consent Exclusion Criteria: * hronic renal failure or metabolic disorders affecting magnesium balance Current use of medications known to significantly interfere with serum magnesium (e.g., long-term diuretics, proton pump inhibitors) unless stable and documented Presence of other comorbid psychiatric disorders Cognitive impairment or language difficulties preventing questionnaire completion

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Conditions

The condition(s) this trial relates to.

depressive disorder major depressive disorder Parasomnias sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depressive disorder Sleep disturbances

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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