Could oxygen or common drugs fix sleep apnea in the elderly?
NCT ID NCT02703220
First seen Jun 26, 2026 · Last updated Aug 21, 2026 · Updated 1 time
Summary
This study tests whether oxygen, acetazolamide, or finasteride can help treat sleep apnea in people aged 60 and older. Researchers will measure how these treatments affect breathing stability during sleep. The goal is to find better, more personalized options for elderly veterans with mild to moderate sleep apnea.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- oxygen, acetazolamide, finasteride
- What this could lead to
- If successful, this could point toward new, personalized treatments for sleep apnea in older adults, potentially reducing related health risks.
- What could go wrong
- This is a small, early-phase study (100 participants) testing multiple interventions. Results may not apply to all patients, and some treatments may cause side effects or prove ineffective.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jul 2015
- Expected to finish
-
Dec 2027
An estimate. End dates often move.
- Lead sponsor
-
A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
60 to 89 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults with mild to moderate sleep apnea with Apnea-Hypopnea Index (AHI)\>/=5 to 20/hour with central, obstructive, mixed apneas and hypopneas * For the finasteride protocol elderly men with above criteria will be enrolled Exclusion Criteria: * Patients with severe sleep apnea (Apnea-Hypopnea Index (AHI)\>20/hour) * Patients with history of prostate cancer * Males with hypogonadism * History of cardiac disease, including myocardial infarction * Bypass surgery * Atrial and ventricular tachy-bradycardias * Systolic congestive heart failure and Cheyne-Stokes respiration * Current unstable angina * Stroke * Schizophrenia * Untreated hypothyroidism * Seizure disorder * Preexisting renal failure and liver disorders * Failure to give informed consent. * Patients with significant pulmonary diseases by history and abnormal pulmonary function testing, including moderate obstructive/restrictive lung/chest wall disorders with resting oxygen saturation of \<96% or on supplemental oxygen * Patients on certain medications including: * study drugs * sympathomimetics/parasympathomimetics or their respective blockers * narcotics * antidepressants * anti-psychotic agents * other central nervous system (CNS) altering medications * current alcohol, tobacco or recreational drug use * Patients with Body mass index (BMI)\>34 kilograms per square meter (kg/m2) will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control * Elderly with unstable gait or mobility issues that may preclude safe participation * Individuals with allergy to finasteride or acetazolamide will be excluded from the specific protocol * Pregnant women
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Elderly adults are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
John D. Dingell VA Medical Center, Detroit, MI
RECRUITINGDetroit, Michigan, 48201-1916, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Smart mask aims to measure blood oxygen through your face
- Agility drills might sharpen aging brains and steady aging steps
- Sleep apnea clues may unmask hidden heart risks in survivors
- Brain training may sharpen aging minds in diabetes
- Could oxygen or a common drug fix Opioid-Linked sleep apnea?
- Personalized sleep apnea treatment on the horizon?